217301-18-3

Upstream product

• 38614-36-7 2-methylpropen-1-ylmagnesium bromide 
• 323195-86-4 (3S)-3-(2-Methoxy-4-methylphenyl)butyl iodide 
• 1001912-82-8 (S)-3-(2-methoxy-4-methylphenyl)butyl 4-methyl-1-benzenesulfonate 
• 217301-10-5 (S)-3-(4-Hydroxymethyl-2-methoxy-phenyl)-butan-1-ol 
• 217301-02-5 4-((S)-2-Furan-2-yl-1-methyl-ethyl)-3-hydroxy-benzoic acid ethyl ester 
• 217301-06-9 4-((S)-2-Carboxy-1-methyl-ethyl)-3-methoxy-benzoic acid ethyl ester 
• 24470-78-8 isopropyltriphenylphosphonium iodide 
• 170423-73-1 (S)-1-[5-(benzyloxy)pentan-2-yl]-2-methoxy-4-methylbenzene 
• 1002320-64-0 C₁₄H₂₂O₂ 
• 279227-20-2 (2S)-5-benzyloxy-2-methyl-1-pentanal 
• 81678-40-2 (2S)-5-(benzyloxy)-2-methylpentan-1-ol 
• 323195-82-0 Ethyl (2E)-3-(2-methoxy-4-methylphenyl)but-2-enoate 
• 35633-35-3 2-methoxy-4-methylacetophenone 
• 851085-93-3 (S)-3-(4-Bromo-2-methoxy-phenyl)-butan-1-ol 

Downstream Products

• 3649-81-8 (S)-curcumene 
• 70878-71-6 (S)-curcuphenol 

Relevant academic research and scientific papers

Total synthesis of s (+)-curcuphenol, s (+)-curcuquinone and s (+)-curcuhydroquinone

A synthesis of (-)-curcuphenol, (-)-curcuquinone and (-)-curcuhydroquinone from o-valerolactone is described. The key steps include an Evans asymmetric methylation of 5-(benzyloxy)pentanoic acid (5), an oxidative aromatization of enone (11) and a regioselective oxidation of the phenol to o-quinone derivative with bis(trifluoro acetate)iodobenzene.

Enantioselective synthesis of (R)- and (S)-curcumene and curcuphenol: an efficient chemoenzymatic route

An efficient enantioselective synthesis of curcumene and curcuphenol is described. The key intermediates, substituted butanoates 7a and 7b and their acids 8a and 8b are obtained in high enantiopurity (>99% ee) by a lipase-catalyzed kinetic resolution proc

Efficient total synthesis of (+)-curcuphenol via asymmetric organocatalysis

The catalytic enantioselective synthesis of (+)-curcuphenol is described herein. This approach involves the use of an organocatalytic alkylation of m-anisidine, a diazotation/Sandmeyer reaction of the amine and a Negishi-type coupling with dimethylzinc. T

Baker's yeast-mediated enantioselective synthesis of the bisabolane sesquiterpenes (+)-curcuphenol, (+)-xanthorrhizol, (-)-curcuquinone and (+)-curcuhydroquinone

Fermenting baker's yeast converts the unsaturated aldehydes 5a-c into the saturated alcohols 6a-c, respectively. The microbial saturation of substrates adsorbed on a nonpolar resin proceeds in high chemical yields and shows complete enantioselectivity in the formation of the (S)-(+) isomers. Enantiopure 6a-c are versatile chiral building blocks for the synthesis of bisabolane sesquiterpenes. Their usefulness is shown in the preparation of (S)-(+)-curcuphenol, (S)-(+)-xanthorrhizol, (S)-(-)-curcuquinone and (S)-(+)-curcuhydroquinone. The Royal Society of Chemistry 2000.

A new enantioselective route to bisabolane sesquiterpenes phenols: Synthesis of (S)-(+)-curcuphenol and (S)-(+)-curcumene

(S)-(+)-Curcuphenol 1 and (S)-(+)-curcumene 2 were synthesised starting from enantiopure (R)-(-)-3-furyl-2-methylpropanol 3 and building up the phenolic ring through a benzoannulation reaction.