217309-46-1

Basic information

• Product Name: 5-(tert-butyldimethylsilyloxy)-2,3-isopropylidenedioxy-D-ribofuranose
• Synonyms: 5-(tert-butyldimethylsilyloxy)-2,3-isopropylidenedioxy-D-ribofuranose
• CAS NO: 217309-46-1
• Molecular Weight: 304.459
• Mol File: 217309-46-1.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: 5-(tert-butyldimethylsilyloxy)-2,3-isopropylidenedioxy-D-ribofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(tert-butyldimethylsilyloxy)-2,3-isopropylidenedioxy-D-ribofuranose(217309-46-1)
• EPA Substance Registry System: 5-(tert-butyldimethylsilyloxy)-2,3-isopropylidenedioxy-D-ribofuranose(217309-46-1)

Safety Data

• Hazardous Substances Data: 217309-46-1(Hazardous Substances Data)

Upstream product

• 75467-36-6 5-O-(tert-butyldimethylsilyl)-2,3-O-isopropylidene-D-ribonolactone 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 154976-38-2 (2R,3S,4S)-1-O-<(1,1-Dimethylethyl)dimethylsilyl>-2-hydroxy-6-methyl-3,4-O-(1-methylethylidene)hept-5-ene 
• 532-20-7 D-Ribose 
• 154976-39-3 (3S,4S)-1-O-<(1,1-Dimethylethyl)dimethylsilyl>-2-hydroxy-6-methyl-3,4-O-(1-methylethylidene)hept-5-en-2-one 
• 30725-00-9 2,3-O-isopropylidene-D-ribonic-γ-lactone 
• 116669-77-3 (1R,4'R,5'S)-(-)-1-(2',2'-dimethyl-5'-vinyl-1',3'-dioxolan-4'-yl)-2-(tert-butyldimethylsilyloxy)-1(R)-ethan-1-ol 
• 50-69-1 D-ribose 
• 532-20-7 D-(-)-ribose 

Downstream Products

• 115479-40-8 4-chloro-7-{5′-O-[(1,1-dimethylethyl)-dimethylsilyl]-2′,3′-O-(1-methylethylidene)-β-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidine-2-amine 
• 863398-02-1 (4S,5R)-4-Benzyloxymethyl-2,2-dimethyl-5-(R)-oxiranyl-[1,3]dioxolane 
• 934356-92-0 (R)-2-Benzyloxy-2-((4R,5S)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol 
• 934356-91-9 [(R)-2-Benzyloxy-2-((4R,5S)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethoxy]-tert-butyl-dimethyl-silane 
• 1332640-35-3 benzyl benzyl((S)-1-((4S,5R)-5-((R)-2-(tert-butyldimethylsilyloxy)-1-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)allyl)carbamate 
• 1332640-36-4 benzyl benzyl((S)-1-((4S,5R)-5-((R)-2-(tert-butyldimethylsilyloxy)-1-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxyethyl)carbamate 
• 1332640-37-5 3-benzyl-4-((4S,5R)-5-((R)-2-(tert-butyldimethylsilyloxy)-1-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)oxazolidin-2-one 
• 1332640-38-6 (S)-3-benzyl-4-((4S,5R)-5-((R)-1,2-dihydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-oxazolidin-2-one 
• 1332640-40-0 (S)-3-benzyl-4-((4S,5R)-2,2-dimethyl-5-((Z)-tetradec-1-enyl)-1,3-dioxolan-4-yl)oxa-zolidin-2-one 
• 1332640-34-2 (R)-1-{(4R,5S)-5-[(S)-1-(benzylamino)allyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-(tert-butyldimethylsilyloxy)ethanol 

Relevant articles and documents

Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD+-dependent enzymes

Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from D-ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.

Synthesis of two arsenic-containing cyclic ethers: model compounds for a novel group of naturally-occurring arsenolipids

Two previously unknown arsenic-containing cyclic ethers have been synthesized, namely (((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)methyl)dimethylarsine oxide and its C-1 epimer (((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)methyl)dimethylarsine oxide as its trifluoroacetate salt. The compounds serve as model compounds for a new group of unidentified arsenolipids observed in a unicellular alga and sediments.

Differentially Protected Ribofuranoid Glycals

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[...] and its preparation method (by machine translation)

The invention relates to the field of chemical synthesis, in particular of formula (III) or formula (IV) shown nucleoside salt and its preparation method. The method of the invention is simple in operation, route the succinct, higher yield, the reagents used are commonly used reagents, in the laboratory can be conveniently 10 - 100 g stage of preparation, can be suitable for large-scale preparation. (by machine translation)

CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE

Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.