217309-46-1Relevant academic research and scientific papers
Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD+-dependent enzymes
Batoux, Nathalie E.,Paradisi, Francesca,Engel, Paul C.,Migaud, Marie E.
, p. 6609 - 6617 (2004)
Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from D-ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.
Synthesis and application of an enantiomerically pure triflate analogue of microbially derived 3-halo- cis -1,2-dihydrocatechol acetonides
Sun, Fenglai,Metz, Peter
, p. 457 - 460 (2013)
(1S,2S)-3-Trifloxy-cis-1,2-dihydrocatechol acetonide, a useful chiral building block, was prepared from d-ribose in good overall yield using a carbonyl allylation and a ring-closing metathesis as the key C-C bond-forming steps. Negishi cross-coupling of this triflate with a serine-derived organozinc iodide proceeded efficiently to afford an α-amino acid derivative as a potential precursor for scabrosin esters (ambewelamides). Georg Thieme Verlag Stuttgart · New York.
Synthesis of two arsenic-containing cyclic ethers: model compounds for a novel group of naturally-occurring arsenolipids
Guttenberger, Nikolaus,Glabonjat, Ronald A.,Jensen, Kenneth B.,Zangger, Klaus,Francesconi, Kevin A.
, p. 4578 - 4580 (2016)
Two previously unknown arsenic-containing cyclic ethers have been synthesized, namely (((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)methyl)dimethylarsine oxide and its C-1 epimer (((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)methyl)dimethylarsine oxide as its trifluoroacetate salt. The compounds serve as model compounds for a new group of unidentified arsenolipids observed in a unicellular alga and sediments.
A convenient large scale synthesis of protected D-ribonolactone from D-ribose
Kaskar,Heise,Michalak,Vishnuvajjala
, p. 1031 - 1032 (1990)
A simple and efficient synthesis of protected D-ribonolactone, a key chiral precursor used in the syntheses of neplanocin A and cyclopentenylcytosine from readily available D-ribose is reported.
S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS
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, (2021/06/22)
Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.
[...] and its preparation method (by machine translation)
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, (2019/10/23)
The invention relates to the field of chemical synthesis, in particular of formula (III) or formula (IV) shown nucleoside salt and its preparation method. The method of the invention is simple in operation, route the succinct, higher yield, the reagents used are commonly used reagents, in the laboratory can be conveniently 10 - 100 g stage of preparation, can be suitable for large-scale preparation. (by machine translation)
CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE
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, (2017/10/11)
Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
Palladium(II)-catalyzed intramolecular aminoacetoxylation of sugar derived alkenyl tosylsulfonamide: Total synthesis of L-deoxyallonojirimycin
Das, Pintu,Ajay, Sama,Shaw, Arun K.
, p. 419 - 422 (2017/01/10)
Palladium catalyzed intramolecular aminoacetoxylation of D-ribose derived alkenyl tosylsulfonamide to deliver L-deoxyallonojirimycin in an overall yield of 19%. The preliminary screening of L-deoxyallonojirimycin against carbohydrate processing enzymes showed moderate inhibitory activity against α-glucosidase (yeast) and α-mannosidases.
SUBSTITUTED NUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS
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Paragraph 0237; 0239, (2016/09/26)
Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
Asymmetric total synthesis of (-)-mangiferaelactone by using an appropriately substituted thiophene as a masked synthon for C-alkyl glycoside
Kumar, Rajan,Rej, Rohan Kalyan,Nanda, Samik
, p. 751 - 759 (2015/07/15)
Abstract Asymmetric total synthesis of naturally occurring nonenolide (-)-mangiferaelactone was attempted through RCAM (ring closing alkyne metathesis) reaction. As the attempted RCAM reaction failed, the synthesis was finally achieved by successful explo
