21731-84-0Relevant academic research and scientific papers
Some 3-Thioxo/Alkylthio-1,2,4-triazoles with a Substituted Thiourea Moiety as Possible Antimycobacterials
Kuecuekguezel, Ilkay,Kuecuekguezel, S. Gueniz,Rollas, Sevim,Kiraz, Muammer
, p. 1703 - 1708 (2007/10/03)
A series of novel N-alkyl/aryl-N'-[4-(4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thione-5-yl)phenyl]thioureas 1-19 and three S-alkylated representatives of the former, N-alkyl/aryl-N'-[4-(3-aralkylthio-4-alkyl/aryl-4H-1,2,4-triazole-5-yl)phenyl]thioureas 20-22, were synthesized and tested for antimycobacterial activity against Mycobacterium tuberculosis H37Rv as well as Mycobacterium fortuitum ATCC 6841 which is a rapid growing opportunistic pathogen. Compounds 4 and 9-11 were found to possess the same MIC value with that of Tobramycin against M. fortuitum ATCC 6841 whereas 1-3 and 21 had positive response against M. tuberculosis H37Rv at varying degrees. Compound 21 was identified as the most potent derivative of the 1-22 series by an MIC value of 6.25 μg/ml and selectivity index of 1.6
Chemotherapeutic Agents. IX. Synthesis and Pesticidal Activities of Bisalkanes and 1-Aryl/alkyl-3-thiourea and Related Compounds
Ram, Vishnu J.,Dube, Vidyottama,Pieters, Luc A. C.,Vlietinck, Arnold J.
, p. 625 - 628 (2007/10/02)
Various bisalkanes (3) were prepared from base cyclization of bis thiosemicarbazide 2 and transformed into sulphides by reaction with different alkyl halides in alkaline medium.These compounds were further oxid
