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Usage

Uses

Used in Organic Synthesis:
1-(3-iodophenyl)-2,5-dimethyl-1H-pyrrole is used as a building block in organic synthesis for the creation of diverse chemical compounds. Its unique structure allows for the development of new molecules with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(3-iodophenyl)-2,5-dimethyl-1H-pyrrole is utilized as a key intermediate for the synthesis of pharmaceuticals. Its presence in the molecular structure can contribute to the biological activity and therapeutic potential of the resulting compounds.
Used in Medicine:
1-(3-iodophenyl)-2,5-dimethyl-1H-pyrrole is employed in the development of pharmaceuticals due to its potential to be incorporated into molecules with medicinal properties. Its unique structural features can enhance the efficacy and selectivity of drugs targeting specific diseases or conditions.
Used in Materials Science:
This pyrrole derivative also finds applications in materials science, where its structural attributes can be leveraged to create new materials with specialized properties for various industrial and technological applications.

Upstream product

• 645-00-1 m-iodonitrobenzene 
• 110-13-4 2,5-hexanedione 
• 626-01-7 3-Iodoaniline 

Downstream Products

• 32570-19-7 1-(3-methoxyphenyl)-2,5-dimethyl-1 H-pyrrole 
• 536-90-3 m-Anisidine 

Relevant academic research and scientific papers

Cascade Synthesis of Pyrroles from Nitroarenes with Benign Reductants Using a Heterogeneous Cobalt Catalyst

A bifunctional 3d-metal catalyst for the cascade synthesis of diverse pyrroles from nitroarenes is presented. The optimal catalytic system Co/NGr-C@SiO2-L is obtained by pyrolysis of a cobalt-impregnated composite followed by subsequent selective leaching. In the presence of this material, (transfer) hydrogenation of easily available nitroarenes and subsequent Paal–Knorr/Clauson-Kass condensation provides >40 pyrroles in good to high yields using dihydrogen, formic acid, or a CO/H2O mixture (WGSR conditions) as reductant. In addition to the favorable step economy, this straightforward domino process does not require any solvents or external co-catalysts. The general synthetic utility of this methodology was demonstrated on a variety of functionalized substrates including the preparation of biologically active and pharmaceutically relevant compounds, for example, (+)-Isamoltane.

2,5-dimethylpyrrole protection facilitates copper(I)-mediated methoxylations of aryl iodides in the presence of anilines

Converting iodoanilines to the corresponding 2,5-dimethylpyrroles was found to facilitate CuCI-mediated methoxide substitution. Examples with ortho-, meta-, or para-relationships between the iodide and aniline are presented. Several other aniline blocking groups were investigated and found not to be successful in this sequence.