217318-90-6

Basic information

• Product Name: 1-Ethyl-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine
• Synonyms: NNC-45-0095; 4-(1-Ethylpyrrolo[2,1,5-cd]indolizin-2-yl)phenol
• CAS NO: 217318-90-6
• Molecular Formula: C₁₈H₁₅NO
• Molecular Weight: 261.32635
• Mol File: 217318-90-6.mol

Chemical Properties

• CAS DataBase Reference: 1-Ethyl-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Ethyl-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine(217318-90-6)
• EPA Substance Registry System: 1-Ethyl-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine(217318-90-6)

Safety Data

• Hazardous Substances Data: 217318-90-6(Hazardous Substances Data)

Upstream product

• 622-39-9 2-propylpyridine 
• 4254-67-5 2-bromo-1-(4-benzyloxyphenyl)-1-ethanone 
• 267226-07-3 3-(4-benzyloxy-phenyl)-4-ethyl-pyrrolo[2,1,5-cd]indolizine-1,2-dicarboxylic acid 
• 267226-06-2 3-(4-benzyloxy-phenyl)-4-ethyl-pyrrolo[2,1,5-cd]indolizine-1,2-dicarboxylic acid dimethyl ester 
• 217302-87-9 2-(4-benzyloxyphenyl)-1-ethylindolizine 
• 267226-08-4 2-(4-benzyloxy-phenyl)-1-ethyl-pyrrolo[2,1,5-cd]indolizine 

Relevant articles and documents

Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor

1-Ethyl-2-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine (NNC 45-0095) is a novel compound which represents the parent pharmacophore structure of a series of pyrrolo[2,1,5-cd]indolizine derivatives with mixed estrogen agonist/antagonist properties. NNC 45-0095 binds with high affinity to the estrogen receptor (IC50 = 9.5 nM) and exhibits full protection of bone loss in the ovariectomized mouse model for post-menopausal osteoporosis. (C) 2000 Elsevier Science Ltd. All rights reserved.

Synthesis and estrogen receptor binding affinities of novel pyrrolo[2,1,5-cd]indolizine derivatives

A series of pyrrolo[2,1,5-cd]indolizine derivatives has been synthesized and evaluated as ligands for the estrogen receptor. Properly substituted mono- and di-hydroxy derivatives showed binding in the low nanomolar range in accordance with their structural resemblance to estrogen. (C) 2000 Elsevier Science Ltd.

Pyrrolo [2,1,5-cd] indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes

The present invention relates to therapeutically active compounds of formula I a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.