217319-01-2Relevant academic research and scientific papers
Discovery of diphenyloxazole and Nδ-Z-ornithine derivatives as highly potent and selective human prostaglandin EP4 receptor antagonists
Hattori, Kouji,Tanaka, Akira,Fujii, Naoaki,Takasugi, Hisashi,Tenda, Yoshiyuki,Tomita, Masayuki,Nakazato, Shoko,Nakano, Keiko,Kato, Yasuko,Kono, Yutaka,Murai, Hidetsugu,Sakane, Kazuo
, p. 3103 - 3106 (2007/10/03)
Two novel classes of diphenyloxazole and Nδ-Z-ornithine derivatives as highly potent and selective EP4 antagonists have been discovered. The optimized diphenyloxzole 8 and Nδ-Z-ornithine 11 effectively competed with [3H]-PGE2/s
