21741-00-4

Upstream product

• 108-86-1 bromobenzene 
• 719-59-5 5-chloro-2-aminobenzophenone 

Downstream Products

• 105104-37-8 7-chloro-1,5-dihydro-1-methyl-5,5-diphenyl-4,1-benzoxazepin-2(3H)-one 
• 105104-39-0 5-chloro-1-methyl-3,3-diphenyl-2-indolinemethanol 
• 105104-38-9 5-chloro-1-methyl-3,3-diphenyl-2-indolinecarboxaldehyde 
• 98414-60-9 7-chloro-1,5-dihydro-5,5-diphenyl-4,1-benzoxazepin-2-(3H)-one 
• 98414-59-6 N-(2-chloroacetyl)-4-chloro-α-hydroxy-α,α-diphenyl-o-toluidyne 

Relevant academic research and scientific papers

The Barbier-Grignard-Type Arylation of Ketones and Unexpected Cross-Coupling of Phenolic Ketones using Unactivated Aryl Bromides

A novel, highly versatile and efficient method has been developed for the Barbier-Grignard-type arylation of ketones and an unexpected cross-coupling of phenolic ketones was observed using unactivated bromides and magnesium in tetrahydrofuran/toluene at 96°C promoted by multicatalysts of cupric bromide (15 mol%), bismuth chloride (5 mol%) and silver bromide (10 mol%). The substituent and electronic effects on the reaction have been discussed. High yields of arylation and cross-coupling have been attained under mild conditions. A novel reasonable mechanism involving a quinone intermediate is proposed. The high chemical selectivity in the cross-coupling to the hydroxy group of phenolic ketones should help ketones find new applications.