217494-82-1Relevant academic research and scientific papers
Sequential catalytic asymmetric allylic transfer reaction: Enantioselective and diastereoselective construction of tetrahydropyran units
Yu, Chan-Mo,Lee, Jae-Young,So, Byungran,Hong, Junghyun
, p. 161 - 163 (2002)
Useful tetrahydropyran units such as 3 can be prepared with high diastereoselectivity (d.r. > 30:1). A key step is the catalytic asymmetric allyl-transfer reaction from 1 to achiral aldehydes catalyzed by [{(R) binol}TiIV{OCH(CF3)2}2] to give 2 (90-97% ee). A second allyl-transfer reaction from 2 to a carbonyl compound leads to 3. binol = 2,2′-binaphthol.
