217499-44-0

Basic information

• Product Name: (2S,6S,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-phenylpiperidine
• Synonyms: (2S,6S,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-phenylpiperidine
• CAS NO: 217499-44-0
• Molecular Weight: 295.425
• Mol File: 217499-44-0.mol

Chemical Properties

• CAS DataBase Reference: (2S,6S,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,6S,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-phenylpiperidine(217499-44-0)
• EPA Substance Registry System: (2S,6S,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-phenylpiperidine(217499-44-0)

Safety Data

• Hazardous Substances Data: 217499-44-0(Hazardous Substances Data)

Upstream product

• 191470-45-8 (3R,5S)-5-methyl-3-phenyl-2,3,5,6,7,8-hexahydro-oxazolo[3,2-a]pyridine 

Relevant articles and documents

Stereocontrolled preparation of cis- and trans-2,6-dialkylpiperidines via diastereoselective reaction of 1-aza-4-oxabicyclo[4.3.0]nonane derivatives with Grignard reagents

We report here the syntheses of cis- and trans-2,6-disubstituted piperidines using chiral 1-aza-4-oxabicyclo[4.3.0]nonane synthon 1, which shows high reactivity toward nucleophilic attack at its C-5 position. Bicyclic compounds resembling synthon 1 were transformed to cis- and trans- 2,6-disubstituted piperidine derivatives via reactions with various Grignard reagents in a stereospecific manner. Using this methodology, (+)-solenopsin A (2b) and both enantiomers of isosolenopsin A (3a and 3b) were synthesized in an enantioselective manner from a single enantiomeric source.