191470-45-8

Upstream product

• 88057-01-6 (3R,5S)-5-Methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile 
• 205526-58-5 (R)-2-[((S)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol 
• 104713-83-9 2-methyl-2-cyano-6-oxazolo[a]piperidine 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 
• 56613-80-0 D-2-phenylglycinol 
• 205526-52-9 (2R,4R)-2-(3-[1,3]Dioxolan-2-yl-propyl)-4-phenyl-3-(2,4,6-trimethoxy-benzyl)-oxazolidine 
• 204845-22-7 (R)-N-2,4,6-trimethoxybenzylphenylglycinol 

Downstream Products

• 104713-86-2 (2S,6R,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-undecylpiperidine 
• 104642-02-6 (2S,6S,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-undecylpiperidine 
• 217499-57-5 (2R,6S,1'R)-N-(2-hydroxy-1-phenylethyl)-2-ethynyl-6-methylpiperidine 
• 156873-51-7 (6S)-1-[(1R)-2-hydroxy-1-phenylethyl]-6-methyl-2-piperidone 
• 5119-88-0 (S)-2-methylpiperidine hydrochloride 
• 217499-53-1 (2S,6R,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-[(E)-undec-3-en-1-ynyl]piperidine 
• 217499-56-4 (2R,6S,1'R)-N-(2-hydroxy-1-phenylethyl)-2-ethenyl-6-methylpiperidine 
• 217499-46-2 (2S,6R,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-phenylpiperidine 
• 217499-44-0 (2S,6S,1'R)-N-(2-hydroxy-1-phenylethyl)-2-methyl-6-phenylpiperidine 
• 205526-59-6 (2S,1'R)-N-2'-hydroxy-1'-phenylethyl-2-methylpiperidine 
• 191470-42-5 (-)-(2'R)-((2S,6S)-2,6-dimethylpiperidin-1-yl)-2'-phenylethanol 
• 88154-74-9 (2S,6R)-1-[(1'R)-2'-hydroxy-1'-phenylethyl]-2-methyl-6-propylpiperidine 

Relevant academic research and scientific papers

Controlled reduction of 5-alkyl-3-phenyl-2,3,5,6,7,8-hexahydro-oxazolo[3,2- a]pyridin-4-ylium iodide: Enantioselective synthesis of (-)-dihydropinidine and (+)-indolizidine 167B

A controlled reduction of (+)-(3R,5S)-5-methyl- and (+)-(3R,5S)-5-n-propyl- 3-phenyl-2,3,5,6,7,8-hexahydro-oxazolo[3,2-a]pyridin-4-ylium iodide 1 and 2 to generate (3R,5S)-5-methyl- and (3R,5S)-5-n-propyl-3-phenyl-2,3,5,6,7,8- hexahydro-oxazolo[3,2-a]pyri

Reductive and oxidative transformations of the N-(cyanomethyl)oxazolidine system to expand the chiral pool of piperidines

Two new reactions have been exploited to modify piperidine scaffolds containing the chiral, non-racemic N-(cyanomethyl)oxazolidine system. A Raney nickel mediated decyanation was studied first, followed by an oxidative process using potassium permanganate

Facile diastereoselective reactions of chiral 1,3-oxazolidines with grignard reagents; asymmetric syntheses of 2-substituted and 2,6-disubstituted piperidines

(S)- and (R)-2-Phenylpiperidines, (S)- and (R)-2-methylpiperidines, meso- and (2R, 6R)-2,6-diphenylpiperidines, and meso- and (25, 65)-2,6-dimethylpiperidines were synthesized asymmetrically starting from the diastereoselective addition of Grignard reagents to chiral 1,3-oxazolidines, converting of 1-aza-4-oxabicyclo[4.3.0]nonane derivatives as pivotal intermediates.