21752-33-0

Usage

InChI:InChI=1/C12H15NO3/c1-9(10-5-3-2-4-6-10)13-11(14)7-8-12(15)16/h2-6,9H,7-8H2,1H3,(H,13,14)(H,15,16)/t9-/m1/s1

Upstream product

• 108-30-5 succinic acid anhydride 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 816431-99-9 C₉H₁₃N*C₁₂H₁₅NO₃ 
• 1227845-02-4 C₉H₁₃N*C₁₂H₁₅NO₃ 

Relevant academic research and scientific papers

PROCESS FOR ENANTIOMERIC ENRICHMENT OF 2 ', 6 ' - PIPECOLOXYLIDIDE

The invention discloses a process for enantiomeric enrichment of 2',6'-pipecoloxylidide using a chiral carbamoyl benzoic acid to provide (S)-enantiomer in high yield and high enantiomeric purity. The invention also discloses novel intermediates formed in the process of enantiomeric enrichment of 2',6'-pipecoloxylidide, preparation of N- substituted amidic acids and alkylation of 2',6'-pipecoloxylidide.

Asymmetric induction via metalation of succinic esters and amide using S(+) menthol and R(+) 1-Phenylethylamine as chiral auxiliaries

The synthesis of chiral esters and amides with the involvement of asymmetric induction by using pure chiral auxiliaries such as (1S, 2R, 5R) menthol and L-(+)-1-phenylethylamine is described. The chiral mono, di menthol esters and mono amides of succinic acid were synthesized in good yields. These esters and amides were then subjected to metalation and quenched with different alkyl halides to get α substitution to generate a new chiral center.

PYRROLIDINE CARBOXAMIDE COMPOUNDS

Pyrrolidine carboxamide compounds are provided. Some such pyrrolidine carboxamide compounds include agonists of sst4 which may be useful for the treatment and prevention of pain and inflammatory disorders.