21758-94-1 Usage
General Description
(2-acetyl-4-chlorophenoxy)acetic acid, also known as fenoxaprop-P-ethyl, is a chemical compound commonly used as an herbicide to control annual and perennial grasses. It belongs to the aryloxyphenoxypropionate class of herbicides and works by inhibiting the enzyme acetyl-CoA carboxylase, which is essential for fatty acid synthesis in plants. This disruption in lipid metabolism ultimately leads to the death of the target grasses. The chemical is known for its selective control of grassy weeds in various crops, including rice, wheat, and barley. It is often formulated as an emulsifiable concentrate or a water dispersible granule for application in the agriculture industry. Although effective at controlling grassy weeds, it is important to handle and apply (2-acetyl-4-chlorophenoxy)acetic acid with caution due to its potential toxicity to aquatic organisms and mammals.
Check Digit Verification of cas no
The CAS Registry Mumber 21758-94-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,5 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 21758-94:
(7*2)+(6*1)+(5*7)+(4*5)+(3*8)+(2*9)+(1*4)=121
121 % 10 = 1
So 21758-94-1 is a valid CAS Registry Number.
21758-94-1Relevant articles and documents
Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase
Nittoli, Thomas,Curran, Kevin,Insaf, Shabana,DiGrandi, Martin,Orlowski, Mark,Chopra, Rajiv,Agarwal, Atul,Howe, Anita Y. M.,Prashad, Amar,Floyd, M. Brawner,Johnson, Bernard,Sutherland, Alan,Wheless, Karen,Feld, Boris,O'Connell, John,Mansour, Tarek S.,Bloom, Jonathan
, p. 2108 - 2116 (2008/02/06)
A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5B polymerase has been identified. The inhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as determined by X-ray crystallography of the enzyme-inhibitor complex. Guided by both molecular modeling and traditional SAR, the enzyme activity of the initial hit was improved by approximately 100-fold, yielding a series of potent and selective NS5B inhibitors with IC50 values as low as 10 nM. These compounds were also inhibitors of the HCV replicon in cultured HUH7 cells.
