217653-39-9Relevant academic research and scientific papers
Kinetic resolution of racemic lactones by conjugate additions of allylic organolithium species: Direct formation of three contiguous centers with high diastereo- and enantioselectivities
Lim, Sung H.,Beak, Peter
, p. 2657 - 2660 (2007/10/03)
(Matrix presented) Kinetic resolution of racemic α,β-unsaturated lactones by the organolithium species produced from asymmetric lithiation of N-Boc-N-(p-methoxyphenyl)cinnamylamine provides conjugate addition products with three contiguous stereogenic centers in yields of 62-77% with diastereomeric ratios from 75:25 to >99:1 and enantiomeric ratios for the major diastereomers from 94:6 to 98:2.
Asymmetric syntheses of fused bicyclic compounds by conjugate additions of allylic organolithium species to activated olefins and subsequent cyclizations.
Lim,Curtis,Beak
, p. 711 - 714 (2007/10/03)
[reaction: see text]. Addition of the configurationally stable organolithium species produced by enantioselective deprotonation of N-Boc-N-(p-methoxyphenyl) allylamines to alpha,beta-unsaturated carbonyl compounds affords 1,4-addition products in good yie
Solid-state structural investigation of an organolithium (-)-sparteine complex: η3-N-Boc-N-(p-methoxyphenyl)-3-phenylallyl-lithium · (-)-sparteine
Pippel, Daniel J.,Weisenburger, Gerald A.,Wilson, Scott R.,Beak, Peter
, p. 2522 - 2524 (2007/10/03)
A η3 monomeric alkyllithium · (-)-sparteine complex has been isolated and characterized in the solid state (see picture). Determination of the absolute configuration of this key intermediate in asymmetric metalation/substitution sequences of N-
