21767-35-1

Usage

Uses

Used in Pharmaceutical Industry:
3-[3-(Trifluoromethyl)phenyl]pyrrolidine is used as a building block for the synthesis of pharmaceuticals, leveraging its stability and bioavailability to contribute to the development of new drug candidates. The trifluoromethyl group enhances the compound's lipophilicity, potentially improving drug absorption and distribution within the body.
Used in Agrochemical Industry:
In the agrochemical sector, 3-[3-(Trifluoromethyl)phenyl]pyrrolidine serves as a key intermediate in the creation of agrochemicals, where its properties can be harnessed to develop effective and stable pesticides or other agricultural chemicals.
Used in Medicinal Chemistry Research:
3-[3-(Trifluoromethyl)phenyl]pyrrolidine is utilized as a valuable tool in medicinal chemistry for studying structure-activity relationships. Its unique structural features allow researchers to explore how modifications to the molecule affect biological activity, which is crucial for optimizing drug design and discovering novel therapeutic agents.

Upstream product

• 178482-88-7 3-(3-Trifluoromethyl-phenyl)-2,3-dihydro-pyrrole-1-carboxylic acid methyl ester 
• 60050-38-6 3-(3-trifluoromethyl-phenyl)-pyrrolidine-2,5-dione 
• 861965-61-9 1-benzyl-3-[3-(trifluoromethyl)phenyl]pyrrolidine 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 178483-05-1 3-(3-Trifluoromethyl-phenyl)-pyrrolidine-1-carboxylic acid methyl ester 

Downstream Products

• 861965-62-0 1-(4-fluorophenyl)-3-{3-[3-(trifluoromethyl)phenyl]pyrrolidin-1-yl}propan-1-one 

Relevant academic research and scientific papers

Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase

Inorganic pyrophosphatases are potential targets for the development of novel antibacterial agents. A pyrophosphatase-coupled high-throughput screening assay intended to detect o-succinyl benzoic acid coenzyme A (OSB CoA) synthetase inhibitors led to the unexpected discovery of a new series of novel inorganic pyrophosphatase inhibitors. Lead optimization studies resulted in a series of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazine derivatives that were prepared by an efficient synthetic pathway. One of the tetracyclic triazine analogues 22h displayed promising antibiotic activity against a wide variety of drug-resistant Staphylococcus aureus strains, as well as activity versus Mycobacterium tuberculosis and Bacillus anthracis, at a concentration that was not cytotoxic to mammalian cells.

Oximes and hydrazones that are useful in treating sexual dysfunction

The present invention relates to oximes and hydrazones of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: Pharmacological evaluation for central dopaminergic and serotonergic activity

A series of 3-arylpyrrolidines has been synthesised via palladium catalyzed arylation and evaluated for dopaminergic and serotonergic activity in vitro and in vivo. Compounds substituted by electron withdrawing groups on the meta position of the aromatic ring, were found to be preferential dopamine autoreceptor antagonists.