21772-34-9

Upstream product

• 67-56-1 methanol 
• 526-62-5 2,5-bis(1-aziridinyl)-1,4-benzoquinone 
• 75-31-0 isopropylamine 
• 106-51-4 p-benzoquinone 
• 24171-03-7 2,5-Diamino-1,4-benzenediol bis hydrochloride 
• 1521-06-8 2,5-diaminocyclohexa-2,5-diene-1,4-dione 
• 123-31-9 hydroquinone 

Relevant academic research and scientific papers

Dinuclear RuIIcomplexes with quinonoid bridges: Tuning the electrochemical and spectroscopic properties of redox-switchable NIR dyes through judicious bridge design

Bridging quinonoid ligands are important platforms for generating metal-based switchable optoelectronic and magnetic materials. A possible sound way of influencing the properties of the aforementioned materials is to modify the direct metal-ligand interfa

Synthesis, biological evaluation, and molecular docking studies of 2,5-substituted-1,4-benzoquinone as novel urease inhibitors

A series of 2,5-substituted-1,4-benzoquinone (1-6) were prepared and structurally characterized by elemental analysis, IR spectra, 1H and 13C NMR spectra, and single crystal X-ray determination. The urease inhibitory activities of the compounds against H. pylori urease were studied. Among the compounds, 2,5-bis(2-morpholin-4-ylethylamino)-[1,4]benzoquinone (2) shows the most effective activity with IC50 value of 27.30 ± 2.17 μM. Docking simulation was performed to insert compound 2 into the crystal structure of H. pylori urease at the active site to determine the probable binding mode. As a result, compound 2 may be used as a potential urease inhibitor.

THYMOQUINONE ANALOGS FOR THE TREATMENT OF PANCREATIC CANCER

Analogs of thymoquinone, an active compound extracted from Nigellasativa (black seed oil) are 2,5-bis (alkyl/aryl amino) 1, 4-benzoquinones, are more potent than the naturally-occurring compound (e.g, have a lower IC50) in terms of inhibition o

Straightforward synthesis of substituted p-Quinones: Isolation of a key intermediate and use as a bridging ligand in a diruthenium complex

(Figure Presented) Keep it simple: A new transamination method is reported for the synthesis of diamino-substituted p-quinones (see scheme). Asymmetrically substituted p-quinones are shown to be key intermediates in this reaction. The redox properties of these ligands are discussed and their utility in coordination and redox chemistry is shown with a representative example.

Synthesis and biological evaluation of 2,5-bis(alkylamino)-1,4- benzoquinones

A series of twelve 2,5-bis(alkylamino)-1,4-benzoquinones were prepared in yields ranging from 9-58% via the reaction between p-benzoquinone and various amines. The structures of the synthesized compounds were confirmed by IR, 1H- and 13/s

Structure-activity studies on therapeutic potential of thymoquinone analogs in pancreatic cancer

Purpose: Pancreatic cancer (PC) is one of the deadliest of all tumors. Previously, we were the first to show that Thymoquinone (TQ) derived from black seed (Nigella sativa) oil has anti-tumor activity against PC. However, the concentration of TQ required

Synthesis of 2,5-Diaminoquinones by one-pot copper-catalyzed aerobic oxidation of hydroquinones and addition reaction of amines

The aerobic oxidation of various hydroquinones was achieved by using copper nanoparticles entrapped in aluminum oxyhydroxide [Cu/ AlO(OH)] at room temperature. Furthermore, 2,5diamino-1,4-benzoquinones were synthesized directly from hydroquinone and amines by a one-pot procedure consisting of the copper-catalyzed aerobic oxidation of hydroquinones and the double addition of amines to the resulting quinones.