217797-14-3

Basic information

• Product Name: paroxetine Mesylate
• Synonyms: paroxetine Mesylate;Asimia;Paroxetine methanesulfonate;POT.mes;(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine methanesulfonate
• CAS NO: 217797-14-3
• Molecular Formula: CH₄O₃S*C₁₉H₂₀FNO₃
• Molecular Weight: 425.47
• Mol File: 217797-14-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 453.6°C at 760 mmHg
• Flash Point: 189.2°C
• Appearance: /
• Vapor Pressure: 2.03E-08mmHg at 25°C
• CAS DataBase Reference: paroxetine Mesylate(CAS DataBase Reference)
• NIST Chemistry Reference: paroxetine Mesylate(217797-14-3)
• EPA Substance Registry System: paroxetine Mesylate(217797-14-3)

Safety Data

• Hazardous Substances Data: 217797-14-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 217797-14-3 differently. You can refer to the following data:
1. Treatment of major depressive disorder, obsessive compulsive disorder, and panic disorder (selective serotonin reuptake inhibitor).
2. Paroxetine Mesylate is a selective serotonin reuptake inhibitor in treatment of depression in human, dog, cat, horse and parrot.

Brand name

Pexeva (JDS).

InChI:InChI=1/C19H21NO3.CH4O3S/c1-2-4-14(5-3-1)17-8-9-20-11-15(17)12-21-16-6-7-18-19(10-16)23-13-22-18;1-5(2,3)4/h1-7,10,15,17,20H,8-9,11-13H2;1H3,(H,2,3,4)/t15-,17-;/m0./s1

Synthetic route

(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-1-carboxylic acid phenyl ester (253768-88-6) → paroxetine mesylate (217797-14-3)

Conditions	Yield
With potassium hydroxide; methanesulfonic acid In toluene

Upstream product

• 253768-88-6 (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-1-carboxylic acid phenyl ester 

Relevant articles and documents

Process for the production of paroxetine

The synthesis of paroxetine can be made more convenient by using a solvent system comprising an aliphatic alcohol and a hydrocarbon co-solvent. The solvent system is used particularly in the hydrolysis of paroxetine phenylcarbamate and preferably uses butanol and toluene as the system.