217797-14-3

Usage

Uses

Used in Pharmaceutical Industry:
Paroxetine Mesylate is used as an antidepressant for the treatment of major depressive disorder, obsessive-compulsive disorder, and panic disorder. It helps to regulate serotonin levels in the brain, providing relief from the symptoms associated with these conditions.
Used in Veterinary Medicine:
Paroxetine Mesylate is also used as a selective serotonin reuptake inhibitor in the treatment of depression in animals, such as dogs, cats, horses, and parrots. It helps to improve the mood and overall well-being of these animals, making it an essential tool for veterinary professionals.
Brand Name:
The brand name for Paroxetine Mesylate is Pexeva, which is marketed and distributed by JDS. This brand is widely recognized and trusted for its effectiveness in treating various mental health disorders in both humans and animals.

InChI:InChI=1/C19H21NO3.CH4O3S/c1-2-4-14(5-3-1)17-8-9-20-11-15(17)12-21-16-6-7-18-19(10-16)23-13-22-18;1-5(2,3)4/h1-7,10,15,17,20H,8-9,11-13H2;1H3,(H,2,3,4)/t15-,17-;/m0./s1

Synthetic route

(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-1-carboxylic acid phenyl ester (253768-88-6) → paroxetine mesylate (217797-14-3)

Conditions	Yield
With potassium hydroxide; methanesulfonic acid In toluene

Upstream product

• 253768-88-6 (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine-1-carboxylic acid phenyl ester 

Relevant academic research and scientific papers

Process for the production of paroxetine

The synthesis of paroxetine can be made more convenient by using a solvent system comprising an aliphatic alcohol and a hydrocarbon co-solvent. The solvent system is used particularly in the hydrolysis of paroxetine phenylcarbamate and preferably uses butanol and toluene as the system.

Paroxetine derivatives

Piperidine compounds, processes for preparing them, pharmaceutical compositions comprising them and their use in therapy are disclosed.