21780-62-1Relevant academic research and scientific papers
Promising bio-active complexes of platinum(II) and palladium(II) derived from heterocyclic thiourea: Synthesis, characterization, DFT, molecular docking, and anti-cancer studies
Al-Janabi, Ahmed S.,Al-Jibori, Subhi A.,Alqahtani, Ali S.,Faihan, Ahmed S.,Hatshan, Mohammad R.,Kadhim, Mustafa M.,Nasr, Fahd A.,Saleh, Abdulrahman M.
, (2021/12/30)
Four Platinum(II) and Palladium(II) heterocyclic thiourea complexes have been prepared; [Pt(CPPT)2](1), [Pd(CPPT)2](2), [Pt(MPPT)2](3), and [Pd(MPPT)2](4) (Where HCPPT=1-(5-chloropyridin-2-yl)-3-phenylthiourea,
Diversity-Oriented Synthesis of Thiazolidine-2-imines via Microwave-Assisted One-Pot, Telescopic Approach and Its Interaction with Biomacromolecules
Saikia, Ananya Anubhav,Rao, Ramdas Nishanth,Maiti, Barnali,Balamurali, Musuvathi Motilal,Chanda, Kaushik
, p. 630 - 640 (2020/12/15)
In this work, a one-pot, telescopic approach is described for the combinatorial library of thiazolidine-2-imines. The synthetic manipulation proceeds smoothly via the reaction of 2-aminopyridine/pyrazine/pyrimidine with substituted isothiocyanates followed by base catalyzed ring closure with 1,2-dibromoethane to obtain thiazolidine-2-imines with broad substrate scope and high functional group tolerance. The synthetic strategy merges well with the thiourea formation followed by base catalyzed ring closure reaction for the thiazolidine-2-imine synthesis in a more modular and straightforward approach. The synthetic procedure reported herein represents a cleaner route toward thiazolidine-2-imines as compared to traditional methodologies. Moreover, the biological significance of combinatorially synthesized thiazolidin-2-imines has been investigated for their use as possible inhibitors for acetyl cholinesterase through molecular docking studies.
