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217817-01-1

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217817-01-1 Usage

Description

Tos-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Check Digit Verification of cas no

The CAS Registry Mumber 217817-01-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,7,8,1 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 217817-01:
(8*2)+(7*1)+(6*7)+(5*8)+(4*1)+(3*7)+(2*0)+(1*1)=131
131 % 10 = 1
So 217817-01-1 is a valid CAS Registry Number.

217817-01-1Relevant articles and documents

CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS

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, (2021/10/30)

Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.

Quinazoline derivative containing 2-nitroimidazole and application of quinazoline derivative

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Paragraph 0033-0036, (2021/06/23)

The invention belongs to the field of medicinal chemistry, and particularly relates to a quinazoline derivative of 2-nitroimidazole. The quinazoline derivative has a structure as shown in the specification, wherein R1 and R2 are respectively and independe

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

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Paragraph 000384; 000385, (2021/03/02)

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

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