252881-73-5Relevant articles and documents
Amphiphilic Cyclodextrin-Based Liquid Crystals for Proton Conduction
Champagne, Pier-Luc,Ester, David,Polan, Danielle,Williams, Vance E.,Thangadurai, Venkataraman,Ling, Chang-Chun
, p. 9217 - 9224 (2019)
Novel cyclodextrin (CD)-based amphiphilic poly(carboxylic acid)s that self-assemble into highly ordered smectic liquid crystalline mesophases were investigated as a novel class of protonic conductors. These structurally well-defined materials are synthesized from nontoxic and environment-friendly CDs, which possess a unique face-to-face pseudosymmetry. By taking advantage of such geometry, a series of flexible tetraethylene glycol groups terminated with a carboxylic acid functionality were introduced to the CD's secondary face, resulting in the formation of long-range 2D hydrogen-bond networks in the smectic mesophases over a wide temperature window. This new material was found to exhibit impressive proton conductivities in solid states, up to 1.4 × 10-2 S cm-1 at 70 °C and 95% humidity. This constitutes the first report of amphiphilic CD-based liquid crystals applied as proton conductive materials.
CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES
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, (2020/01/31)
A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.
A CONJUGATE OF AN AMANITA TOXIN WITH BRANCHED LINKERS
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, (2020/08/22)
Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.