217824-80-1Relevant academic research and scientific papers
Racemic, yet diastereomerically pure azido acids as both γ-turn and inverse γ-turn mimetics for solid-phase peptide synthesis
Schmidt, Boris,Kühn, Christian
, p. 1240 - 1242 (2007/10/03)
The chemoselective arylation of cyclohexane-1,3,5-tricarboxylate derivatives gave access to ketodiesters. Corey's variation of Mukayama's 2-mercaptopyridine activation was superior to acid chlorides and Weinreb amides. The obtained meso-diesters were desymmetrized by L-Selectride and further elaborated to azido acids. These azido acids (e.g. 7) are novel γ-turn templates for solid-phase synthesis of peptides such as 8a and 8b.
