21787-81-5

Basic information

• Product Name: 4'-chloro-2-formotoluidide
• Synonyms: 4'-chloro-2-formotoluidide;4-CHLORO-N-FORMYL-ORTHO-TOLUIDINE;2'-Methyl-4'-chloroformanilide;N-(4-Chloro-2-methylphenyl)formamide;4'-CHLORO-O-FORMOTOLUIDIDE
• CAS NO: 21787-81-5
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.62
• Mol File: 21787-81-5.mol

Chemical Properties

• Boiling Point: 306.5°C (rough estimate)
• Flash Point: 155.4°C
• Appearance: /
• Density: 1.1885 (rough estimate)
• Vapor Pressure: 0.000137mmHg at 25°C
• Refractive Index: 1.5430 (estimate)
• CAS DataBase Reference: 4'-chloro-2-formotoluidide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-chloro-2-formotoluidide(21787-81-5)
• EPA Substance Registry System: 4'-chloro-2-formotoluidide(21787-81-5)

Safety Data

• Hazardous Substances Data: 21787-81-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8ClNO/c1-6-4-7(9)2-3-8(6)10-5-11/h2-5H,1H3,(H,10,11)

Upstream product

• 94-69-9 2'-methylformanilide 
• 64-18-6 formic acid 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 95-53-4 o-toluidine 

Downstream Products

• 95-69-2 4-chloro-2-methylbenzeneamine 
• 2771-66-6 4-Chlor-2-methyl-phenylisocyanid-dichlorid 
• 41657-13-0 (4-Chloro-2-methyl-phenyl)-[1-piperidin-1-yl-meth-(Z)-ylidene]-amine 
• 77486-37-4 (4-Chloro-2-methyl-phenyl)-[1-morpholin-4-yl-meth-(Z)-ylidene]-amine 
• 37407-77-5 N-(2-Methyl-4-chlorphenyl)-N'-methyl-N'-butyl-formamidin 
• 77486-42-1 N'-(2-methyl-4-chlorophenyl)-N-cyclohexylformamidine 
• 41657-06-1 C₁₄H₂₁ClN₂ 
• 77486-36-3 N,N-Dibutyl-N'-(4-chloro-2-methyl-phenyl)-formamidine 
• 77486-38-5 N'-(2-methyl-4-chlorophenyl)-N,N-diallylformamidine 
• 74702-11-7 C₆H₃Cl(CH₃)N(CHO)SCFCl₂ 

Relevant articles and documents

Method for synthesizing P-chloroO-toluidine

The invention discloses a method for synthesizing p-chloroo-toluidine, which comprises the following steps: synthesizing o-toluidine and a protective agent in an organic solvent to obtain an amino-protected intermediate. The amino protected intermediate is added into hydrochloric acid, an oxidant is added for chlorination reaction, and a chlorination product is obtained. The chlorinated product is removed and the amino protecting group is removed to give p-chloroo-toluidine. The method for synthesizing p-chloroo-toluidine provided by the invention is high in yield, simple to operate, less in three wastes, high in product content and good in quality, and can be suitable for industrial mass production.

Co3O4 nanoparticles prepared by oxidative precipitation method: an efficient and reusable heterogeneous catalyst for N-formylation of amines

Abstract: N-formylation of different amines was carried out with formic acid in the presence of the Co3O4 nanoparticles as an efficient, stable heterogeneous catalyst to give the corresponding formamides under solvent-free conditions. This method has advantages over the reported methods such as high yields, mild conditions, easy work-up and short reaction times. The catalyst was characterized by different techniques such as XRD, SEM and FT-IR spectroscopy. Graphical Abstract: [Figure not available: see fulltext.]