21788-28-3

Basic information

• Product Name: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-
• Synonyms: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-;1-(4-methoxyphenyl)-1,2,3,4-tetrazole;1-(4-Methoxy-phenyl)-1H-tetrazole;1-(4-methoxyphenyl)-1H-tetrazole;1-(4-methoxyphenyl)tetrazole
• CAS NO: 21788-28-3
• Molecular Formula: C₈H₈N₄O
• Molecular Weight: 176.18
• Mol File: 21788-28-3.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 327.9°Cat760mmHg
• Flash Point: 152.1°C
• Appearance: /
• Density: 1.3g/cm³
• CAS DataBase Reference: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-(21788-28-3)
• EPA Substance Registry System: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-(21788-28-3)

Safety Data

• Hazardous Substances Data: 21788-28-3(Hazardous Substances Data)

Usage

Uses

1-(4-Methoxyphenyl)-1H-tetrazole is used in synthesis, in-silico molecular modeling, anti-diabetic, antibacterial and antifungal activities of aryl-N-tosyl-tetrazole-carboxamides.

Upstream product

• 104-94-9 4-methoxy-aniline 
• 122-51-0 orthoformic acid triethyl ester 
• 100-17-4 para-methoxynitrobenzene 
• 1895-39-2 sodium chlorodifluoroacetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 26060-35-5 N-(4-methoxyphenyl)thioformamide 
• 10349-38-9 p-methoxyphenylisonitrile 
• 5470-34-8 4-methoxyformanilide 

Downstream Products

• 57761-73-6 1-(4'-methoxyphenyl)-5-phenyl-1H-tetrazole 
• 7472-54-0 N-(p-methoxyphenyl)benzamide 
• 1571902-00-5 5-(2,2-dioxido-1,2-benzoxathiin-6-yl)-1-(4-methoxyphenyl)-1H-tetrazole 
• 1352545-35-7 5-(3,4,5-trimethoxyphenyl)-1-(4-methoxyphenyl)-1H-tetrazole 
• 168267-02-5 2-methoxy-5-tetrazol-1-yl-benzaldehyde 

Relevant articles and documents

Practical synthesis of tetrazoles from amides and phosphorazidates in the presence of aromatic bases

Tetrazoles were effectively synthesized from amides using diphenyl phosphorazidate or bis(p-nitrophenyl) phosphorazidate in the presence of aromatic bases. Various amides underwent the proposed cycloaddition reaction to provide the corresponding tetrazoles. Studies on the racemization of chiral substrates were also performed. Overall, the proposed synthesis method enables the preparation of 1,5-disubstituted and 1-substituted tetrazoles, and 5-substituted 1H-tetrazoles without using toxic or explosive reagents.

Oxidation/ MCR domino protocol for direct transformation of methyl benzene, alcohol, and nitro compounds to the corresponding tetrazole using a three-functional redox catalytic system bearing TEMPO/Co(III)-porphyrin/ Ni(II) complex

A redox catalytic system for oxidation-reduction reactions and the domino preparation of tetrazole compounds from nitro and alcohol precursors was designed, prepared and characterized by UV–vis, GPC, TGA, XRD, EDX, XPS, VSM, FE-SEM, TEM, DLS, BET, NMR, and ICP analyses. The catalyst was prepared via several successive steps by demetalation of chlorophyll b, copolymerization with acrylated TEMPO monomers, complexation with Ni and Co metals (In two different steps), then immobilized on magnetic nanoparticles. The presence of three functional groups including TEMPO, coordinated cobalt, and coordinated nickel in the catalyst, allowed the oxidation of various types of alcohols, alkyl benzenes as well as the reduction of nitro compounds by a single catalyst. All reactions yielded up to 97 % selectivity for oxidation and reduction reactions. Next, the ability of the catalyst to successfully convert alcohol, methyl benzenes and nitro to their corresponding tetrazoles was studied.

Polymer-Supported Fe-Phthalocyanine Derived Heterogeneous Photo-Catalyst for the Synthesis of Tetrazoles Under Visible Light Irradiation

Abstract: Herein, a polymer supported Fe-Phthalocyanine entangled with carboxyl functionalized benzimidazolium moiety (PSFePcCFBM) explored as heterogenous photocatalyst, for regioselective synthesis of 1H-tetrazoles from sodium azide and other affordable