217939-33-8Relevant academic research and scientific papers
Enantioselective synthesis of cyclic α-aminoboronates via copper-catalyzed dearomative borylation of 4-quinolinols
Xu, Ming,Ouyang, Yizhao,Wang, Linghua,Zhang, Shuai,Li, Pengfei
supporting information, p. 3677 - 3680 (2022/04/07)
A highly enantioselective and regioselective dearomative borylation of 4-quinolinols was developed using a Cu(i)/(R,R)-Ph-BPE catalyst for efficient synthesis of unprecedented heterocyclic α-amino boronates, a new class of compounds potentially relevant to drug discovery, in generally excellent yields and enantioselectivities. The products were also useful intermediates for highly functionalized tetrahydroquinolines and cyclic α-aminoboronate derivatives.
