5443-23-2

Basic information

• Product Name: 4-chloro-6-phenylquinoline
• CAS NO: 5443-23-2
• Molecular Formula: C₁₅H₁₀ClN
• Molecular Weight: 239.6996
• Mol File: 5443-23-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 376.8°C at 760 mmHg
• Flash Point: 213.5°C
• Density: 1.235g/cm³
• Vapor Pressure: 1.53E-05mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 4-chloro-6-phenylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-phenylquinoline(5443-23-2)
• EPA Substance Registry System: 4-chloro-6-phenylquinoline(5443-23-2)

Safety Data

• Hazardous Substances Data: 5443-23-2(Hazardous Substances Data)

Upstream product

• 217939-33-8 6-phenyl-quinolin-4-ol 
• 108-86-1 bromobenzene 
• 65340-70-7 6-bromo-4-chloroquinoline 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1245921-72-5 C₂₅H₂₃N₃O 
• 144653-43-0 N-(4-(4-methylpiperazin-1-yl)phenyl)-6-phenylquinolin-4-amine 
• 1245921-69-0 4-anilino-6-phenyl-quinoline 
• 1245921-71-4 C₂₃H₂₀N₂ 
• 1245921-83-8 C₂₁H₁₅ClN₂O 
• 1245921-70-3 C₂₃H₂₀N₂O 

Relevant articles and documents

A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors

The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot borylation/Suzuki reaction protocol that we applied to the synthesis of various bi- or poly-aryl scaffolds, including a variety of aryl and heteroaryl ring systems and the core frameworks of kinase inhibitors vemurafenib and GDC-0879.