5443-23-2

Upstream product

• 217939-33-8 6-phenyl-quinolin-4-ol 
• 65340-70-7 6-bromo-4-chloroquinoline 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 108-86-1 bromobenzene 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1245921-72-5 C₂₅H₂₃N₃O 
• 144653-43-0 N-(4-(4-methylpiperazin-1-yl)phenyl)-6-phenylquinolin-4-amine 
• 1245921-69-0 4-anilino-6-phenyl-quinoline 
• 1245921-71-4 C₂₃H₂₀N₂ 
• 1245921-83-8 C₂₁H₁₅ClN₂O 
• 1245921-70-3 C₂₃H₂₀N₂O 

Relevant academic research and scientific papers

A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors

The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot borylation/Suzuki reaction protocol that we applied to the synthesis of various bi- or poly-aryl scaffolds, including a variety of aryl and heteroaryl ring systems and the core frameworks of kinase inhibitors vemurafenib and GDC-0879.

4-Anilino-6-phenyl-quinoline inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2)

A class of inhibitors of mitogen activated protein kinase-activated kinase 2 (MK2) was discovered via high-throughput screening. This compound class demonstrates activity against the enzyme with sub-μM IC50 values, and suppresses LPS-induced TN