21796-15-6

Basic information

• Product Name: 1(2H)-Isoquinolinone, 3,4-dihydro-7-hydroxy-6-methoxy-2-methyl-
• Synonyms: 1(2H)-Isoquinolinone, 3,4-dihydro-7-hydroxy-6-methoxy-2-methyl-;3,4-Dihydro-2-methyl-6-methoxy-7-hydroxyisoquinoline-1(2H)-one;3,4-Dihydro-7-hydroxy-6-methoxy-2-methyl-1(2H)-isoquinolinone;Thalifolin;Thalifoline;7-Hydroxy-6-methoxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
• CAS NO: 21796-15-6
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.23
• Mol File: 21796-15-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 432.1°Cat760mmHg
• Flash Point: 215.1°C
• Appearance: /
• Density: 1.246g/cm³
• Vapor Pressure: 4.51E-08mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1(2H)-Isoquinolinone, 3,4-dihydro-7-hydroxy-6-methoxy-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Isoquinolinone, 3,4-dihydro-7-hydroxy-6-methoxy-2-methyl-(21796-15-6)
• EPA Substance Registry System: 1(2H)-Isoquinolinone, 3,4-dihydro-7-hydroxy-6-methoxy-2-methyl-(21796-15-6)

Safety Data

• Hazardous Substances Data: 21796-15-6(Hazardous Substances Data)

Usage

Description

1(2H)-Isoquinolinone, 3,4-dihydro-7-hydroxy-6-methoxy-2-methylis a simple isoquinoline alkaloid derived from natural sources. It occurs in plants such as Thalictrum minus and Arcangelisia gusanlung. The compound is characterized by its colorless rod-like crystalline structure when recrystallized from methanol (MeOH) and exhibits specific absorption maxima in its ultraviolet spectrum in ethanol (EtOH) at 223.5, 261, and 302 nm. The structure of this compound has been confirmed through synthesis.

Uses

Used in Pharmaceutical Industry:
1(2H)-Isoquinolinone, 3,4-dihydro-7-hydroxy-6-methoxy-2-methylis used as a pharmaceutical compound for its potential therapeutic applications. The compound's unique structure and properties make it a promising candidate for the development of new drugs targeting various health conditions.
Used in Chemical Research:
In the field of chemical research, 1(2H)-Isoquinolinone, 3,4-dihydro-7-hydroxy-6-methoxy-2-methylserves as a valuable compound for studying the properties and reactivity of isoquinoline alkaloids. Its synthesis and structural confirmation contribute to the understanding of the chemical behavior of similar compounds and can lead to the discovery of new synthetic routes and applications.
Used in Natural Product Analysis:
1(2H)-Isoquinolinone, 3,4-dihydro-7-hydroxy-6-methoxy-2-methylis also used in the analysis of natural products, particularly in the identification and characterization of isoquinoline alkaloids found in plants like Thalictrum minus and Arcangelisia gusanlung. The study of such natural products can provide insights into their biological activities and potential applications in medicine and other industries.

References

Doskotch, Schiff, Beal, Tetrahedron, 25, 469 (1969)

InChI:InChI=1/C11H13NO3/c1-12-4-3-7-5-10(15-2)9(13)6-8(7)11(12)14/h5-6,13H,3-4H2,1-2H3

Upstream product

• 493-49-2 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 

Relevant articles and documents

NEW SYNTHESIS OF ISOQUINOLINE ALKALOIDS, THALIFOLINE, CORYPALLINE, AND CHERYLLINE

Isoquinoline alkaloids, thalifoline, corypalline, and cherylline, were synthesised by application of the cyclisation reaction of β-phenyl-ethyl isocyanate to N-methylisoquinoline lactam with Magic Methyl and the regioselective cleavage reaction of aromatic methoxyl groups with methionine and methanesulphanic acid.