21797-84-2

Upstream product

• 2038-57-5 3-Phenylpropan-1-amine 

Downstream Products

• 119878-56-7 benzyl N-<3-(1,4-cyclohexadien-1-yl)propyl>carbamate 
• 1381868-54-7 C₂₉H₂₉NO 
• 1396228-30-0 N-[3-(cyclohexa-1,4-dienyl)propyl](4-dimethylamino)-1,8-naphthalimide 
• 119878-30-7 N-Methyl-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-4-trifluoromethyl-benzamide 
• 119878-34-1 4-Bromo-2-chloro-N-methyl-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzamide 
• 119878-33-0 2-(3,4-Dichloro-phenyl)-N-methyl-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-acetamide 
• 119878-31-8 3,4-Dibromo-N-methyl-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzamide 
• 119878-32-9 3,4-Dichloro-N-methyl-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzamide 
• 119878-27-2 4-Bromo-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzenesulfonamide 
• 119878-38-5 3,4-Dichloro-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzamide 
• 119878-18-1 2-Bromo-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzamide 
• 119878-25-0 2-(4-Bromo-phenyl)-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-acetamide 
• 119878-28-3 4-Bromo-N-methyl-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzamide 
• 119878-23-8 4-Methoxy-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzamide 

Relevant academic research and scientific papers

Birch Reduction of Arenes Using Sodium Dispersion and DMI under Mild Conditions

An easy-to-handle sodium dispersion in paraffin oil (SD), in combination with inexpensive and environmentally benign 1,3- dimethyl-2-imidazolidinone (DMI) as an additive enables the Birch-type reduction of a variety of arenes with high yields, selectivity, and tolerance of functionality such as ether, alcohol, amine, amide, and carboxylic acid.

An alternative route to tethered Ru(II) transfer hydrogenation catalysts

A new route towards a series of tethered η6-arene/Ru(II) catalysts for use in the transfer and pressure hydrogenation of ketones and aldehydes to alcohols is reported. The route proceeds through the formation of an amide from the diamine precursor, followed by reduction, rather than the direct alkylation of the diamine. This has the advantage that dialkylation of the amine is avoided during the synthesis. Through this new route, both racemic and enantiomerically-pure η6-arene/Ru(II) tethered catalysts can be prepared in high yield.

COMPLEXES AND METHODS FOR THEIR PREPARATION

The invention provides methods for the preparation of ligands for complexes, methods for preparing complexes and complexes having those ligands. Also provided is the use of a complex as a catalyst in a method of synthesis.

Synthesis, Opioid Receptor Binding Profile, and Antinociceptive Activity of 1-Azaspirodecan-10-yl Amides

A series of azaspirodecanyl amides were prepared by a novel cyclization route and examined for opiate receptor binding and antinociceptive activity.Selected tertiary amides in this series showed potent selective μ-receptor binding and antinociceptive activity, in contrast to the less conformationally restricted secondary amides, which showed relatively weak activity.Although structurally similar to the κ-agonist U-50488H (1), these compounds showed virtually no tendency to bind to the κ-receptor.An X-ray crystal structure of compound (21) confirms that the spirocyclic amine does not cause distortion away from the chair conformation of the cyclohexane ring.Either this receptor has very specific requirements for the orientation of the two nitrogens of these compounds or this ring system fills a portion of space more readily tolerated by the μ- and ?-receptors.