21798-20-9Relevant academic research and scientific papers
SnCl2·2H2O-Catalyzed Solvent-Free Synthesis of α-Amino Ketones and Tetrasubstituted Pyrazines
Tamaddon, Fatemeh,Dehghani Tafti, Arefeh
, p. 2217 - 2220 (2016)
Solvent-free reaction of various anilines with α-hydroxy ketones catalyzed by SnCl2·2H2O provides α-amino ketones in excellent yields. While a similar reaction with aliphatic amines is applicable for the synthesis of substituted pyrazines, SnCl2·2H2O permits versatility in the solvent-free reaction of α-hydroxy ketones with ammonium acetate to give the corresponding substituted pyrazines in good to excellent yields.
An Improved Synthesis of Multi-Substituted Pyrazines under Catalyst- and Solvent-Free Conditions
Tamaddon, Fatemeh,Tafti, Arefeh Dehghani,Pooramini, Farzaneh
, p. 4295 - 4299 (2016/11/26)
A one-pot pseudo four-component reaction between a variety of 2-hydroxy-1,2-diarylethanone derivatives and ammonium acetate or amines has been developed to synthesize substituted pyrazines under catalyst-free and solvent-free conditions. This procedure provides a synthetic method to access pyrazine derivatives in excellent yields under green conditions.
