21798-20-9Relevant articles and documents
SnCl2·2H2O-Catalyzed Solvent-Free Synthesis of α-Amino Ketones and Tetrasubstituted Pyrazines
Tamaddon, Fatemeh,Dehghani Tafti, Arefeh
, p. 2217 - 2220 (2016)
Solvent-free reaction of various anilines with α-hydroxy ketones catalyzed by SnCl2·2H2O provides α-amino ketones in excellent yields. While a similar reaction with aliphatic amines is applicable for the synthesis of substituted pyrazines, SnCl2·2H2O permits versatility in the solvent-free reaction of α-hydroxy ketones with ammonium acetate to give the corresponding substituted pyrazines in good to excellent yields.