2180-37-2

Basic information

• Product Name: 3-tyrosine
• Synonyms: 3-tyrosine
• CAS NO: 2180-37-2
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 0
• Mol File: 2180-37-2.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 387.2°Cat760mmHg
• Flash Point: 188°C
• Appearance: /
• Density: 1.333g/cm³
• CAS DataBase Reference: 3-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-tyrosine(2180-37-2)
• EPA Substance Registry System: 3-tyrosine(2180-37-2)

Safety Data

• Hazardous Substances Data: 2180-37-2(Hazardous Substances Data)

Upstream product

• 60521-82-6 2-acetylamino-3-(3-hydroxyphenyl)propionic acid methyl ester 
• 14755-02-3 3-hydroxy-trans-cinnamic acid 
• 565458-30-2 2-(3-hydroxybenzyl)malonic acid dimethyl ester 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 63-91-2 L-phenylalanine 
• 1354973-68-4 C₃₀H₃₅NO₃ 
• 64325-07-1 (S)-2-acetylamino-3-(3-hydroxyphenyl)propionic acid 
• 1700-30-7 (3-(benzyloxy)phenyl)methanol 
• 1700-31-8 3-benzyloxybenzyl bromide 
• 775-06-4 D/L-3-hydroxy-phenylalanine 

Downstream Products

• 90819-30-0 (S)-2-((tert-butoxycarbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid 
• 167935-97-9 methyl (S)-2-amino-3-(3-hydroxyphenyl)propanoate 
• 775-06-4 D/L-3-hydroxy-phenylalanine 
• 253143-27-0 (S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid 
• 134388-87-7 (S)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 178432-48-9 Fmoc-3-hydroxy-L-Phe 
• 34260-70-3 methyl (2S)-2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride 
• 64325-07-1 (S)-2-acetylamino-3-(3-hydroxyphenyl)propionic acid 
• 1300035-21-5 methyl (S)-3-(2-bromo-5-methoxyphenyl)2-((tert-butyloxycarbonyl)amino)propanoate 
• 184176-05-4 methyl (S)-2-((tert-butyloxycarbonyl)amino)-3-(3-methoxyphenyl)propanoate 

Relevant articles and documents

Optimized synthesis of L-m-tyrosine suitable for chemical scale-up

This paper demonstrates how L-m-tyrosine 1 can be synthesized on larger-scale via enzyme-catalyzed kinetic resolution of N-acyl m-tyrosine methyl ester 4. N-Acyl m-tyrosme methyl ester 4 was prepared by a modification of Erlenmeyer's azalactone synthesis followed by hydrogenation of the resultant dehydroamino acid 12. The optimized four-step synthesis utilizes cheap and readily available starting materials and circumvents difficult purification protocols.

Deracemization of racemic amino acids using (R)- and (S)-alanine racemase chiral analogues as chiral converters

-

FLUORINE RADIOLABELLING PROCESS

The invention relates to a process for producing a process for producing an 18F-labelled compound, the process comprising treating a compound of formula (I): wherein EDG is an electron-donating group selected from -OH, -OR4, -NHR5 and -NR55R5; R1, R2, X1 and X2 are as defined herein; and R3 is selected from H, X3 and X4, wherein X3 is a monodentate cleavable surrogate group, and X4 is a bidentate cleavable surrogate group which is bonded (a) to said X or X and (b) to the ring carbon atom para to EDG; with [18F]fluoride in the presence of an oxidant, thereby producing, when R3 in the compound of formula (I) is H, an 18F-labelled compound of formula (II), wherein EDG is as defined above and R1, R2, X1 and X2 are as defined herein; or thereby producing, when R3 in the compound of formula (I) is said monodentate cleavable surrogate group X4, a compound of formula (Ilc), wherein EDG' is O, NR5, -NR55R5 or [OR4]+, and wherein R4, R5, R55, R1, R2, X1, X2 and X3 are as defined herein; or thereby producing, when R3 in the compound of formula (I) is said bidentate cleavable surrogate group X4, a compound of formula (IIc) or a compound of formula (IId), wherein EDG' is O, NR5, -NR55R5 or [OR4]+, and wherein R4, R5, R55, R1, R2, X1, X2 and X4 are as defined herein.