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(1,2-diphenylethyl)(diphenyl)phosphane oxide, also known as DPPA, is a phosphorus-based derivative used as a reagent in organic synthesis. It is known for its high reactivity and selectivity in reaction conditions, making it a valuable tool in the pharmaceutical and chemical industries.

2181-47-7

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2181-47-7 Usage

Uses

Used in Pharmaceutical Industry:
(1,2-diphenylethyl)(diphenyl)phosphane oxide is used as a coupling reagent for amide and ester bond formation in peptide and drug synthesis. It is valued for its mild and odorless properties, making it an alternative to other coupling reagents such as HOBt and DIC.
Used in Chemical Industry:
(1,2-diphenylethyl)(diphenyl)phosphane oxide is used in the preparation of complex molecules and natural products due to its unique structure and properties, making it an important and versatile compound in organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 2181-47-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,8 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2181-47:
(6*2)+(5*1)+(4*8)+(3*1)+(2*4)+(1*7)=67
67 % 10 = 7
So 2181-47-7 is a valid CAS Registry Number.

2181-47-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (2-diphenylphosphoryl-2-phenylethyl)benzene

1.2 Other means of identification

Product number -
Other names <1,2-Diphenyl-ethyl>-diphenyl-phosphin-oxid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2181-47-7 SDS

2181-47-7Downstream Products

2181-47-7Relevant academic research and scientific papers

Direct C-OH/P(O)-H dehydration coupling forming phosphine oxides

Chen, Long,Zhu, Yueyue,Chen, Tieqiao,Liu, Long,Zhang, Ji-Shu,Han, Li-Biao

supporting information, p. 5090 - 5093 (2018/07/29)

A t-BuONa-mediated C-OH/P(O)-H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcohols and P(O)-H compounds as the starting materials, providing an efficient alternative method for constructing sp3 C-P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed.

MISE EN EVIDENCE DE LA FLUORESCENCE D'OXYDES D'ARYLPHOSPHINES TERTIAIRES

Bourson, Jean,Oliveros, Laureano

, p. 75 - 82 (2007/10/02)

Fluorescence properties of 14 tertiary phosphine oxides have been investigated.Triphenyl, (phenyl)-alkyldiphenyl and alkyldiphenyl phosphine oxides exhibit only weak fluorescence (quantum yields /= 0.01).On the other hand, when a substituent on the phosp

CONCERNING PHOSPHIRENIUM CATIONS

Breslow, Ronald,Deuring, Lisa A.

, p. 1345 - 1348 (2007/10/02)

Tetraphenyl-, tetraethyl-, and 1,1-diphenyl-2,3-diethylphosphirenium cations can be prepared by extension of a previously desribed procedure, but base-promoted cyclizations of 1,3-dihalophosphonium cations proceed to ring-opened products by an alternate p

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