218168-58-2

Basic information

• Product Name: Glycine, N-(4-cyanophenyl)-, ethyl ester
• Synonyms: Glycine, N-(4-cyanophenyl)-, ethyl ester;N-(4-Cyanophenyl)glycine ethyl ester;N-(4-cyanophenyl)-, ethyl ester Glycine;ethyl 2-(4-cyanoanilino)acetate
• CAS NO: 218168-58-2
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.22518
• Mol File: 218168-58-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 348.3±22.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• PKA: 0.30±0.50(Predicted)
• CAS DataBase Reference: Glycine, N-(4-cyanophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-(4-cyanophenyl)-, ethyl ester(218168-58-2)
• EPA Substance Registry System: Glycine, N-(4-cyanophenyl)-, ethyl ester(218168-58-2)

Safety Data

• Hazardous Substances Data: 218168-58-2(Hazardous Substances Data)

Usage

Description

Glycine, N-(4-cyanophenyl)-, ethyl ester, also known as Ethyl 2-((4-Cyanophenyl)amino)acetate, is an organic compound derived from glycine. It is characterized by the presence of a cyanophenyl group attached to the nitrogen atom and an ethyl ester group. Glycine, N-(4-cyanophenyl)-, ethyl ester is known for its reactivity and utility in the synthesis of various organic molecules.

Uses

Used in Pharmaceutical Industry:
Glycine, N-(4-cyanophenyl)-, ethyl ester is used as a synthetic reagent for the production of dihydroquinazolines and quinolines. These compounds are important in the pharmaceutical industry as they serve as the core structure for various drugs with diverse therapeutic applications, including antihypertensive, antiplatelet, and anticancer agents. The use of this ester in the synthesis process allows for the creation of these biologically active molecules with improved efficiency and selectivity.
Used in Chemical Research:
In the field of chemical research, Glycine, N-(4-cyanophenyl)-, ethyl ester is utilized as a key intermediate in the synthesis of complex organic molecules. Its unique structure and reactivity make it a valuable tool for exploring new chemical reactions and developing novel synthetic pathways. This contributes to the advancement of organic chemistry and the discovery of new compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 105-36-2 ethyl bromoacetate 
• 873-74-5 4-Aminobenzonitrile 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 429658-95-7 3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester 
• 1441049-11-1 diethyl 6-cyano-3-(4-cyanophenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate 

Relevant articles and documents

A series of robust metal-porphyrinic frameworks based on rare earth clusters and their application in N-H carbene insertion

We herein report a series of microporous metal-porphyrinic frameworks (MPFs), denoted as NUPF-2M, based on rare earth (RE) clusters. NUPF-2M represent the first examples of RE cluster-based MPFs, possessing a rarely seen shp-a topology and exhibiting high thermal and thermal stabilities. After a post-metallization process with FeCl3, NUPF-2M is catalytically active as an efficient heterogeneous catalyst for intermolecular N-H carbene insertion.

Molecular Oxygen-Mediated Radical Alkylation of C(sp3)-H Bonds with Boronic Acids

A direct and site-specific alkylation of (sp3)C-H bond with aliphatic boronic acid was achieved. By simply heating glycinates and amines together with alkylboronic acids under an oxygen atmosphere, a variety of unnatural α-amino acids and peptides could b

Dual role of Cu2O nanocubes as templates and networking catalysts for hollow and microporous Fe-porphyrin networks

Cu2O nanocubes were used for the synthesis of hollow and microporous Fe porphyrin networks (H-MFePN). In this synthesis, Cu2O nanocubes performed not only as networking catalysts but also as shape controlling templates. MFePN were formed on the surface of the Cu2O nanocubes through azide-alkyne cycloaddition of tetrakis(4-ethynylphenyl) Fe-porphyrin with 1,4-diazidobenzene. H-MFePN showed excellent catalytic activities in carbene insertion into N-H bonds, maintaining their activities during five recycle tests.