2182-39-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Phenylamino-propionitrile is used as a building block for the synthesis of various drugs and chemicals. Its unique structure allows it to be a key component in the development of new pharmaceutical products.
Used in Organic Synthesis:
2-Phenylamino-propionitrile is used as a reagent in organic synthesis, contributing to the creation of a wide range of chemical compounds for various applications.
Used as a Precursor:
2-Phenylamino-propionitrile serves as a precursor to other chemical compounds, playing a crucial role in the production of various substances.
Used in the Synthesis of Anti-depressant Drugs:
2-Phenylamino-propionitrile is an important intermediate in the production of pharmaceuticals, particularly in the synthesis of anti-depressant drugs, where it contributes to the development of medications aimed at treating depression and related mental health conditions.

Upstream product

• 74-90-8 hydrogen cyanide 
• 6052-11-5 N-ethylideneaniline 
• 75-07-0 acetaldehyde 
• 62-53-3 aniline 
• 60-29-7 diethyl ether 
• 107-13-1 acrylonitrile 
• 78-97-7 2-hydroxy-propionitrile 
• 19481-82-4 2-bromopropionitrile 
• 631-57-2 Acetyl cyanide 
• 143-33-9 sodium cyanide 
• 5919-63-1 N,N'-diphenyl-ethylidenediamine 

Downstream Products

• 154319-63-8 N-Phenyl-N-(α-cyanoethyl)-p-fluorobenzamide 
• 2412-47-7 N-<1-Cyan-aethyl>-N-phenyl-chloressigsaeure-amid 
• 2182-37-8 N-<1-Cyan-aethyl>-N-phenyl-2-chlor-propionsaeure-amid 
• 74-90-8 hydrogen cyanide 
• 5813-88-7 2-(phenylamino)propanamide 
• 105510-39-2 N-(2-propionitrile)-N-phenylcarbamoyl chloride 
• 42164-53-4 (-)-N²-phenyl-propane-1,2-diamine 
• 42164-53-4 (+)-N²-phenyl-propane-1,2-diamine 
• 15727-49-8 N-Phenylalanin 
• 142-04-1 aniline hydrochloride 
• 85599-78-6 Phenyl-trimethylsilanyl-((E)-2-trimethylsilanyl-vinyl)-amine 
• 85599-77-5 Phenyl-trimethylsilanyl-vinyl-amine 

Relevant academic research and scientific papers

Ruthenium (II) β-diketimine as hydroamination catalyst, crystal structure and DFT computations

A new half-sandwich ruthenium (II) complex containing β-diketiminate ligand has been synthesized and used for hydroamination of acrylonitrile with aromatic and aliphatic amines. The catalytic activity of prepared complex was compared with a series of ruthenium complexes of β-diketiminate ligands, and the effect of electronic and steric properties of these ligands on catalytic activity of their complexes was investigated. Replacement of H atom in α position of β-diketiminate with (CF3) as an electron-withdrawing group leads to decreasing the reaction yield, and on the other hand, electron-donating group (CH3) has the opposite effect. In addition, crystal structure of [Ru(p-cymen)Cl(LH,Cl)] was determined by single X-ray crystallography. Hirshfeld surface analysis has been performed to determine the dominate interactions in molecular crystal. Furthermore, density functional, QTAIM and energy calculations have been carried out, to get the detailed insight into electronic and bonding characteristics of titled compound.

Controllable access to multi-substituted imidazoles: Via palladium(II)-catalyzed C-C coupling and C-N condensation cascade reactions

A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles via cascade palladium catalyzed C-C coupling followed by intramolecular C-N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles were firstly reported as starting materials to construct di-, tri-, and tetra-substituted imidazoles in good to excellent yield.

Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct α-cyanoamination of ketones and aldehydes

The first three-component organocatalyzed Strecker reaction operating on water has been developed. The manifold utilizes ketones (aldehydes) as the starting carbonyl component, aniline as the primary amine, acetyl cyanide as the cyanide source and N,N-dim

Benzofuran derivatives and their use as antibacterial agents

The invention relates to novel benzofuran derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.

Open-Chain Reissert Compounds: One-Pot Synthesis and Utility in Synthesis of Unsymmetrical Imides, α-Acylamino Carboxamides, Imidazolinones, and Hydantoins

Acyclic Reissert compounds 2 and bis(Reissert compound)s 3-5 can be conveniently prepared in a biphasic system without isolation of the intermediate α-amino nitriles.Treatment of 2 with sodium hydride affords substituted unsymmetrical imides as 8.Oxidativ