21823-73-4

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

It is a chemical compound derived from the parent compound pyrrolizidine.

Explanation

The compound contains a hydroxymethyl group (-CH2OH) attached to the molecule.

Explanation

It is used as a building block or intermediate in the synthesis of various organic compounds.

Explanation

It is utilized in the development of potential drug candidates for various medical conditions.

Explanation

Studies have been conducted to explore its potential therapeutic effects on neurological disorders and cancer.

Explanation

The structural properties of the compound make it a useful intermediate in the production of other pharmaceuticals and biologically active compounds.

Explanation

The specific arrangement of atoms and functional groups in the molecule contributes to its versatility and potential applications in the pharmaceutical industry.

Derivative of pyrrolizidine

Yes

Hydroxymethyl functional group

Present

Application in organic synthesis

Yes

Application in pharmaceutical research

Yes

Therapeutic effects

Potential

Versatile intermediate

Yes

Structural properties

Important

Upstream product

• 56783-28-9 (2S*,3S*)-2,3-dimethyl hexahydropyrrolo[1,2-b][1,2]oxazole-2,3-dicarboxylate 
• 845753-23-3 [2-oxo-5-(3-trimethylsilanyl-propenyl)-pyrrolidin-1-yl]-thioacetic acid S-ethyl ester 
• 845753-19-7 [2-Oxo-5-((E)-3-trimethylsilanyl-propenyl)-pyrrolidin-1-yl]-acetic acid methyl ester 
• 845753-11-9 N-carbomethoxyamino-5-[3-(trimethylsilyl)-1-propenyl]-2-pyrrolidinone 
• 845753-21-1 [2-Oxo-5-((E)-3-trimethylsilanyl-propenyl)-pyrrolidin-1-yl]-acetic acid 
• 845753-15-3 Methyl-[2-oxo-5-((E)-3-trimethylsilanyl-propenyl)-pyrrolidin-1-yl]-carbamic acid methyl ester 
• 845753-24-4 [2-Oxo-5-((E)-3-trimethylsilanyl-propenyl)-pyrrolidin-1-yl]-acetaldehyde 
• 845753-17-5 5-[3-(trimethylsilyl)-1-propenyl]-2-pyrrolidinone 

Relevant academic research and scientific papers

Cascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition

Simple haloaldehydes, including enolisable aldehydes, were found to be suitable for the formation of cyclic products by cascade (domino) condensation, cyclisation, dipolar cycloaddition chemistry. This multi-component reaction approach to heterocyclic compounds was explored by using hydroxylamine, a selection of aldehydes, and a selection of activated dipolarophiles. Initial condensation gives intermediate oximes that undergo cyclisation with displacement of halide to give intermediate nitrones; these nitrones undergo in situ intermolecular dipolar cycloaddition reactions to give isoxazolidines. The cycloadducts from using dimethyl fumarate were treated with zinc/acetic acid to give lactam products and this provides an easy way to prepare pyrrolizinones, indolizinones, and pyrrolo[2,1-a]isoquinolinones. The chemistry is illustrated with a very short synthesis of the pyrrolizidine alkaloid macronecine and a formal synthesis of petasinecine.

Extremely high regio- and stereoselective C-C bond formation of substituted γ-hydroxylactams: synthesis of macronecines based on their structural duality

With a view to develop a new synthetic entry for the necine bases, treatment of functionalized γ-hydroxylactams was found to undergo quite high regio- and diastereoselective carbon-carbon bond formation reactions, affording the corresponding structurally

Synthesis of the necine bases (±)-macronecine and (±)-supinidine via an aza-ene reaction and allylsilane induced ring closure

An aza-ene reaction has been used for the first time for the synthesis of two 5-membered lactam-hydrazides, each with a built-in allylsilane terminator for further elaboration. One of the lactam-hydrazides was transformed via an allylsilane-hydrazonium io