218273-62-2

Upstream product

• 18495-27-7 1-bromooct-2-yne 
• 3406-02-8 bis(phenylsulfonyl)methane 
• 106-96-7 propargyl bromide 

Downstream Products

• 1333467-08-5 1-(1-methylcyclobutyl)-3,5,5-tris(phenylsulfonyl)octa-1,2-dien-7-yne 
• 1333466-87-7 3-methyl-10,10,12-tris(phenylsulfonyl)bicyclo[6.4.0]dodeca-1⁽¹²⁾,2,7-triene 
• 1333467-24-5 1-(1-methylcyclobutyl)-5,5-bis(phenylsulfonyl)-2,7-octadiyn-1-ol 
• 1414368-19-6 C₃₂H₃₂O₅S₃ 
• 1414368-49-2 (2Z,8Z)-3-methyl-11,11,13-tris(phenylsulfonyl)bicyclo[7.4.0]trideca-1⁽¹³⁾,2,8-triene 
• 1414368-30-1 1-(1-methylcyclopentyl)-3,5,5-tris(phenylsulfonyl)octa-1,2-dien-7-yne 

Relevant academic research and scientific papers

A Rh(I)-Catalyzed Cascade Cyclization of 1,5-Bisallenes and Alkynes for the Formation of cis-3,4-Arylvinyl Pyrrolidines and Cyclopentanes

The cascade cyclization reactions of 1,5-bisallenes grant access to a great variety of products by precisely tuning the catalyst system and/or the reagents involved. Herein, we present our findings that 1,5-bisallenes react with two molecules of dimethyl acetylenedicarboxylate to afford, in a completely diastereoselective manner, cis-3,4-arylvinyl pyrrolidines and cyclopentanes. DFT calculations have been used to postulate a mechanism for the developed reaction which encompasses a [2+2+2] cycloaddition reaction of the two alkynes and the external double bond of one allene, followed by a cycloisomerization involving the internal double bond of the second allene. (Figure presented.).

Stereoselective Synthesis of Exocyclic Tetrasubstituted Vinyl Halides via Ru-Catalyzed Halotropic Cycloisomerization of 1,6-Haloenynes

Herein, a ruthenium-catalyzed cycloisomerization that transforms 1,6-haloenynes into 5-membered carbo- and heterocycles that bear exocyclic, stereodefined, tetrasubstituted vinyl halides is reported. The reaction is insensitive to air and water, tolerates a variety of functional groups, and proceeds with good to excellent stereoselectivity and yield.