218438-53-0Relevant academic research and scientific papers
Addition-Cyclization Reactions of Cinnamoyl Isothiocyanate with Nitrogen and Oxygen Nucleophiles
Ahmed, A. F. Sayed,Aouf, N.,Assy, M. G.
, p. 2056 - 2061 (2007/10/03)
Bithiourea 2 obtained from isothiocyanate 1 and thiosemicarbazide was cyclized to yield triazolopyrimidine (5). Addition cyclization of dibenzylamine or N-methylaniline and compound 1 gave thiazines 7a,b. Refluxing of 1 and sodium ethoxide provided thiazine 8. Reaction of hydrazine and isothiocyanate 1 afforded triazole 12 that reacted with malononitrile or 1,3-cyclohexanedione to give triazolopyridine 14 and triazoloquinoline 16 respectively. The synthesis of triazolothiazine 19 is also described.
