218443-81-3

Upstream product

• 78186-80-8 3,3-dimethyl-4-oxohex-1-ene 
• 186417-88-9 (-)-(5R,6S,7S)-6-hydroxy-8-[(4-methoxybenzyl)oxy]-3,3,5,7-tetramethyloct-1-en-4-one 
• 186417-89-0 (R)-4-[(2S,4S,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2,2-dimethyl-3-oxo-pentanal 
• 186417-92-5 (+)-(2R)-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]-4,4-dimethylhex-5-en-3-one 
• 136320-64-4 (2R)-3-[(4-methoxybenzyl)oxy]-2-methylpropanol 
• 132969-71-2 methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate 
• 132969-60-9 (2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 186417-93-6 (-)-(2R,5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]-4,4-dimethyloct-7-en-3-one 

Relevant academic research and scientific papers

Synthesis of the C(1)-C(9) segment of the cytotoxic macrolides epothilon A and B

The C(1)-C(9) segment 3 of the macrolides epothilon A and B 1, two new cytotoxic natural products, has been synthesized in a direct manner. Key steps in the synthesis are a stereoselective aldol reaction of 6 and 7 and a Brown allylation of 9.