218457-76-2 Usage
Uses
Used in Pharmaceutical Research and Development:
FMOC-ASU-OH is used as a building block for the synthesis of complex peptides and proteins, which are essential for the development of new drugs and therapies. Its role in solid-phase peptide synthesis allows for the creation of a diverse range of bioactive molecules with potential medicinal properties.
Used in Biotechnology:
In the biotechnology industry, FMOC-ASU-OH is used as a key component in the production of recombinant proteins and other bio-engineered molecules. Its application in peptide synthesis contributes to advancements in areas such as protein engineering, vaccine development, and the creation of diagnostic tools.
Used in Academic Research:
FMOC-ASU-OH is utilized as a research tool in academic settings to study the structure, function, and interactions of peptides and proteins. Its application in solid-phase peptide synthesis enables researchers to explore the properties of these biomolecules and gain insights into their biological roles and potential applications.
Used in Diagnostics:
FMOC-ASU-OH is employed in the development of diagnostic assays and tests that rely on specific peptide or protein interactions. Its use in peptide synthesis allows for the production of diagnostic agents with high specificity and sensitivity, improving the accuracy and reliability of medical diagnostics.
Used in Drug Delivery Systems:
FMOC-ASU-OH is used in the design of drug delivery systems that incorporate peptide-based therapeutics. Its role in peptide synthesis enables the development of targeted drug delivery vehicles, improving the efficacy and safety of treatments by ensuring precise delivery to specific cells or tissues.
Check Digit Verification of cas no
The CAS Registry Mumber 218457-76-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,4,5 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 218457-76:
(8*2)+(7*1)+(6*8)+(5*4)+(4*5)+(3*7)+(2*7)+(1*6)=152
152 % 10 = 2
So 218457-76-2 is a valid CAS Registry Number.
218457-76-2Relevant academic research and scientific papers
Solid phase synthesis of hydroxamate peptides for histone deacetylase inhibition
Wilson, David M.,Silverman, Lisa N.,Bergauer, Markus,Keshari, Kayvan R.
, p. 151 - 153 (2013/02/21)
An orthogonal protecting group strategy was devised to synthesize hydroxamic acid containing peptides for biomimetic histone deacetylase (HDAC) inhibition. The basic building block was a protected aminosuberic acid (Asu) derivative bearing a protected hydroxamate in the side-chain, related closely to HDAC inhibitors that are transition-state analogs of acetyllysine. These inhibitors include suberoylanilide hydroxamic acid (SAHA), currently being used to treat a variety of human cancers. This strategy was employed to synthesize a series of nonameric peptides related to actual HDAC substrates, derived from known sites of acetylation/deacetylation on the N-terminal tails of the histone core proteins H2A, H2B, H3, and H4. In each case the lysine residue was replaced by a hydroxamate-bearing side chain, to mimic the endogenous site of deacetylation. Mass spectrometry and high performance liquid chromatography (HPLC) confirmed the success of automated solid-phase synthesis. These results suggest facile synthesis of a new class of HDAC inhibitors that may have enhanced selectivity for specific HDAC isoforms.
