218461-30-4

Upstream product

• 484-65-1 2,3,4,5,6-pentamethylbenzyl chloride 
• 504-63-2 trimethyleneglycol 

Downstream Products

• 218461-40-6 trifluoro-methanesulfonic acid 3-pentamethylphenylmethoxy-propyl ester 
• 218461-34-8 1-(3-pentamethylphenylmethoxy-propyl)-4-vinyloxy-azetidin-2-one 
• 218461-44-0 formic acid 4-oxo-1-(3-pentamethylphenylmethoxy-propyl)-azetidin-2-yl ester 

Relevant academic research and scientific papers

Synthesis of 1-oxacephams via improved cyclization of N-substituted-4- formyloxyazetidin-2-ones

The Lewis acid promoted cyclisation of N-substituted-4- formyloxyazetidin-2-ones, easily available from 4-vinyloxyazetidin-2-one is described. The efficiency of the ring closure reaction, to give 1-oxacephams, depends on the oxygen protected-activated group and the Lewis acid.