218461-45-1

Upstream product

• 95467-63-3 3,5-dimethyl-2,4,6-trimethoxybenzyl chloride 
• 218461-41-7 trifluoro-methanesulfonic acid 3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl ester 
• 218461-31-5 3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propan-1-ol 
• 218461-35-9 1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-4-vinyloxy-azetidin-2-one 

Relevant academic research and scientific papers

Functionalization of a β-lactam ring via nucleophilic displacement of a 4-vinyloxy substituent

A vinyloxy group at C-4 of an azetidin-2-one can be easily displaced by nucleophiles in the presence of a Lewis acid catalyst.

Synthesis of 1-oxacephams via improved cyclization of N-substituted-4- formyloxyazetidin-2-ones

The Lewis acid promoted cyclisation of N-substituted-4- formyloxyazetidin-2-ones, easily available from 4-vinyloxyazetidin-2-one is described. The efficiency of the ring closure reaction, to give 1-oxacephams, depends on the oxygen protected-activated group and the Lewis acid.