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α-Carboimidopropionylchlorid, also known as α-ketopropionyl chloride or 2-oxopropanoyl chloride, is a chemical compound with the molecular formula C3H3ClO2. It is a colorless liquid that is highly reactive due to the presence of the acyl chloride functional group. α-Carboimidopropionylchlorid is used as a reagent in organic synthesis, particularly in the preparation of esters, amides, and other derivatives. It is also employed in the synthesis of pharmaceuticals and agrochemicals. Due to its reactivity, α-carboimidopropionylchlorid must be handled with care, as it can cause severe irritation or burns to the skin, eyes, and respiratory system.

2185-12-8

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2185-12-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2185-12-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,8 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2185-12:
(6*2)+(5*1)+(4*8)+(3*5)+(2*1)+(1*2)=68
68 % 10 = 8
So 2185-12-8 is a valid CAS Registry Number.

2185-12-8Relevant academic research and scientific papers

Organosilicon synthesis of isocyanates: III. Synthesis of aliphatic, carbocyclic, aromatic, and alkylaromatic isocyanatocatboxylic acid esters

Lebedev,Lebedeva,Sheludyakov,Ovcharuk,Kovaleva,Ustinova

, p. 1069 - 1080 (2008/02/05)

A series of aminoacid esters was prepared by treating the aminoacid suspensions in ethanol with thionyl chloride. Best conversion of aminoacid esters to corresponding isocyanates was achieved in the case of aromatic and carbocyclic aminoesters by phosgeneation of their N-silyl derivatives, and in the case of aliphatic and alkylaromatic aminoesters by phosgeneation of O-silyl or N,O-bissilylurethanes on their basis. In the last case additional step of esterification of the by-products isocyanatoalkylcarboxylic acid chlorides is required after phosgeneation. Unusual generation of cynnamates and intramolecular N→O-migration of trimethylsilyl group in the solutions of silylated alkylaromatic β-aminoacid esters were found. Pleiades Publishing, Inc., 2006.

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