21854-76-2

Basic information

• Product Name: 2-[1'-(N-p-methoxyphenylamino)-1'-phenyl]methylcyclohexanone
• Synonyms: 2-[1'-(N-p-methoxyphenylamino)-1'-phenyl]methylcyclohexanone
• CAS NO: 21854-76-2
• Molecular Weight: 309.408
• Mol File: 21854-76-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-[1'-(N-p-methoxyphenylamino)-1'-phenyl]methylcyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1'-(N-p-methoxyphenylamino)-1'-phenyl]methylcyclohexanone(21854-76-2)
• EPA Substance Registry System: 2-[1'-(N-p-methoxyphenylamino)-1'-phenyl]methylcyclohexanone(21854-76-2)

Safety Data

• Hazardous Substances Data: 21854-76-2(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 1613-90-7 4-methoxy-N-[(E)-phenylmethylidene]aniline 

Downstream Products

• 164026-52-2 2-amino-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 

Relevant articles and documents

Mannich-type reaction promoted by an ionic liquid

The Mannich-type reaction of silyl enolates with aldimines occurred smoothly with [emim]OTf as a solvent and without the addition of an activator to afford β-amino carbonyl compounds in excellent yields.

Bronsted acid-surfactant-combined catalyst for the Mannich reaction in water

A series of Bronsted acid-surfactant-combined catalysts (BASCs) functionalised with different acids have been synthesized and applied to catalyze the three-component Mannich reaction with aldehyde, acetone and amine at 25 °C in water. The effects of cation tail length and ions of the ionic liquid and the recyclability of the catalysts and BASC acidity (H0) were investigated. The results demonstrated that the 3-(N,N- dimethyloctylammonium) propanesulfonic acid toluene sulfate ([DOPA][Tos]) provide the best catalytic activity because of the formation of emulsions during the reaction. The catalytic procedure was simple and the catalyst could be recycled 9 times by simple separating processes without noticeably decreasing the catalytic activity. The Royal Society of Chemistry 2014.

Heteropoly acid in ionic liquid - An efficient and recyclable system for one-pot three-component Mannich reaction

This paper describes a one-pot three-component Mannich reaction, catalyzed by phosphotungstic acid (H3PW12O40), a heteropoly acid in ionic liquid. The catalyst was found to be mild and efficient, and the protocol affords β-arnino ketones in good yields under ambient conditions. Several ionic liquids and conventional organic solvents were employed for the reaction. The ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) offered the best results in terms of yield of the products. It was observed that a Homogeneous reaction medium proved beneficial for the yield of the reaction.