218594-15-1

Basic information

• Product Name: 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE
• Synonyms: 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE;2-BROMO-5-AMINOPYRIDINE, N-BOC PROTECTED;2-BROMO-5-BOC-AMINOPYRIDINE;2-Bromo-5-aminopyridine, N-BOC protected 95%;tert-butyl 6-bromopyridin-3-ylcarbamate;5-Amino-2-bromopyridine, 5-BOC protected 95%;tert-butyl N-(6-broMopyridin-3-yl)carbaMate;(6-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS NO: 218594-15-1
• Molecular Formula: C₁₀H₁₃BrN₂O₂
• Molecular Weight: 273.13
• Product Categories: Amines;blocks;Bromides;Pyridines;Pyridine
• Mol File: 218594-15-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 124-126
• Boiling Point: 300.96 °C at 760 mmHg
• Flash Point: 135.816 °C
• Appearance: /
• Density: 1.454 g/cm³
• Vapor Pressure: 0.00109mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE(218594-15-1)
• EPA Substance Registry System: 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE(218594-15-1)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 218594-15-1(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-(tert-butoxycarbonylamino)pyridine is a chemical compound with the molecular formula C12H15BrN2O3. It is a pyridine derivative with a bromine atom at position 2 and a tert-butoxycarbonylamino group at position 5. 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in research and development as a building block in the production of various organic compounds. The tert-butoxycarbonylamino group is a protecting group for the nitrogen atom, which allows for specific reactions to be carried out without affecting this part of the molecule. Overall, 2-Bromo-5-(tert-butoxycarbonylamino)pyridine has important applications in the field of organic chemistry and as a precursor for various valuable compounds.

InChI:InChI=1/C10H13BrN2O2/c1-10(2,3)15-9(14)13-7-4-5-8(11)12-6-7/h4-6H,1-3H3,(H,13,14)

Upstream product

• 13534-97-9 6-bromopyridine-3-amine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1022641-52-6 6-bromo-N-methylpyridin-3-amine 
• 1259524-94-1 tert-butyl (6-(phenylethynyl)pyridin-3-yl)carbamate 
• 849353-27-1 (6-phenylpyridin-3-yl)carbamic acid ter-butyl ester 

Relevant articles and documents

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PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES

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Switchable cucurbituril-bipyridine beacons

4-Aminobipyridine derivatives form strong inclusion complexes with cucurbit[6]uril, exhibiting remarkably large enhancements in fluorescence intensity and quantum yields. The remarkable complexation-induced pKa shift (ΔpKa =3.3) highlights the strong charge-dipole interaction upon binding. The reversible binding phenomenon can be used for the design of switchable beacons that can be incorporated into cascades of binding networks. This concept is demonstrated herein by three different applications: 1) a switchable fluorescent beacon for chemical sensing of transition metals and other ligands; 2) direct measurement of binding constants between cucurbit[6]uril and various nonfluorescent guest molecules; and 3) quantitative monitoring of biocatalytic reactions and determination of their kinetic parameters. The latter application is illustrated by the hydrolysis of an amide catalyzed by penicillin G acylase and by the elimination reaction of a b-cabamoyloxy ketone catalyzed by aldolase antibody 38C2.