218600-48-7

Basic information

• Product Name: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid
• Synonyms: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid
• CAS NO: 218600-48-7
• Molecular Formula: C₃₁H₄₅NO₃
• Molecular Weight: 479.701
• Product Categories: Pentacyclic Triterpenes
• Mol File: 218600-48-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid(218600-48-7)
• EPA Substance Registry System: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid(218600-48-7)

Safety Data

• Hazardous Substances Data: 218600-48-7(Hazardous Substances Data)

Upstream product

• 508-02-1 Oleanolic acid 
• 17990-42-0 Oleanonsaeure 
• 303114-51-4 oleanolic acid benzyl ester 
• 892869-59-9 (4aS,6aS,6bR,8aR,12aR,12bR,14bS)-11-[1-Hydroxy-meth-(Z)-ylidene]-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid benzyl ester 
• 869788-74-9 (4aS,6aS,6bR,12aR)-benzyl 2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate 
• 892869-60-2 C₃₈H₅₁NO₃ 
• 218600-47-6 (4aS,6aS,6bR,8aR,12aR,12bR,14bS)-11-Formyl-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid 

Relevant articles and documents

Novel heterocyclic ring-fused oleanolic acid derivatives as osteoclast inhibitors for osteoporosis

Osteoporosis is a major public health problem in our aging society. In the present study, a series of novel oleanolic acid (OA) derivatives were synthesized via modifications in the A-ring and C-28 position of OA, and their anti-bone resorption activities

Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

A series of maslinic acid derivatives have been synthesized by introducing various fused heterocyclic rings at C-2 and C-3 positions. Their inhibitory effects on PTP1B, TCPTP and related PTPs are evaluated. Most of the compounds exhibited a dramatic increase in inhibitory potency and selectivity, the two most potent PTP1B inhibitors 20 (IC50 = 0.61 μM) and 29 (IC50 = 0.64 μM) showed about 10-fold more potent than lead compound maslinic acid. More importantly, 29 possesses the best selectivity of 6.9-fold for PTP1B over TCPTP.

Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages

New derivatives with electron-withdrawing substituents at the C-2 position of 3-oxoolean-1-en-28-oic acid were synthesized. Among them, 2- cyano-3,12-dioxoleam-1,9-dien-28-oic acid (CDDO) was 400 times more potent than previous compounds we have made as an inhibitor of production of nitric oxide induced by interferon γ in mouse macrophages (IC50, 0.4 nM). The potency of CDDO was similar to that of dexamethasone, although CDDO does not act through the glucocorticoid receptor.