218600-48-7

Basic information

• Product Name: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid
• Synonyms: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid
• CAS NO: 218600-48-7
• Molecular Formula: C₃₁H₄₅NO₃
• Molecular Weight: 479.701
• Product Categories: Pentacyclic Triterpenes
• Mol File: 218600-48-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid(218600-48-7)
• EPA Substance Registry System: Oleana-2,12-dieno[2,3-d]isoxazol-28-oic acid(218600-48-7)

Safety Data

• Hazardous Substances Data: 218600-48-7(Hazardous Substances Data)

Upstream product

• 508-02-1 Oleanolic acid 
• 17990-42-0 Oleanonsaeure 
• 303114-51-4 oleanolic acid benzyl ester 
• 892869-59-9 (4aS,6aS,6bR,8aR,12aR,12bR,14bS)-11-[1-Hydroxy-meth-(Z)-ylidene]-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid benzyl ester 
• 869788-74-9 (4aS,6aS,6bR,12aR)-benzyl 2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate 
• 892869-60-2 C₃₈H₅₁NO₃ 
• 218600-47-6 (4aS,6aS,6bR,8aR,12aR,12bR,14bS)-11-Formyl-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid 

Relevant articles and documents

Therapeutic compounds and methods of use

Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.

Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

A series of maslinic acid derivatives have been synthesized by introducing various fused heterocyclic rings at C-2 and C-3 positions. Their inhibitory effects on PTP1B, TCPTP and related PTPs are evaluated. Most of the compounds exhibited a dramatic increase in inhibitory potency and selectivity, the two most potent PTP1B inhibitors 20 (IC50 = 0.61 μM) and 29 (IC50 = 0.64 μM) showed about 10-fold more potent than lead compound maslinic acid. More importantly, 29 possesses the best selectivity of 6.9-fold for PTP1B over TCPTP.

Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages

New derivatives with electron-withdrawing substituents at the C-2 position of 3-oxoolean-1-en-28-oic acid were synthesized. Among them, 2- cyano-3,12-dioxoleam-1,9-dien-28-oic acid (CDDO) was 400 times more potent than previous compounds we have made as an inhibitor of production of nitric oxide induced by interferon γ in mouse macrophages (IC50, 0.4 nM). The potency of CDDO was similar to that of dexamethasone, although CDDO does not act through the glucocorticoid receptor.