218608-98-1 Usage
Uses
Used in Medicinal Chemistry:
BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID is used as a building block for the synthesis of pharmaceuticals, due to its unique structural features that may allow for the development of drugs targeting specific biological pathways or receptors.
Used in Drug Development:
In the pharmaceutical industry, BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID is used as a precursor in the design and synthesis of new drugs, potentially leading to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Research and Testing:
BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID serves as a research compound for studying its chemical properties, reactivity, and potential interactions with biological targets, which is crucial for understanding its applicability in drug discovery and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 218608-98-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,6,0 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 218608-98:
(8*2)+(7*1)+(6*8)+(5*6)+(4*0)+(3*8)+(2*9)+(1*8)=151
151 % 10 = 1
So 218608-98-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H20FNO4/c1-15(2,3)21-14(20)17-11(9-13(18)19)8-10-6-4-5-7-12(10)16/h4-7,11H,8-9H2,1-3H3,(H,17,20)(H,18,19)/t11-/m1/s1
218608-98-1Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
