851307-02-3

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 218608-98-1 (3R)-3-[(tert-butoxycarbonyl)amino]-4-(2-fluorophenyl)butanoic acid 

Downstream Products

• 872322-62-8 tert-butyl {(1R)-1-(2-fluorobenzyl)-3-[(1-methyl-2-oxo-1,2,3,4-tetrahydro-1,5-naphthyridin-3-yl)amino]-3-oxopropyl}carbamate 
• 872322-53-7 tert-butyl ((1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl)amino]propyl)carbamate 
• 872322-47-9 tert-butyl {(1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2,3,4-tetrahydro-1,5-naphthyridin-3-yl)amino]propyl}carbamate 
• 872322-45-7 tert-butyl {(1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)amino]propyl}carbamate 
• 851307-04-5 {(R)-2-(2-fluorophenyl)-1-[((R)-1-methylcarbamoyl-2-thiophen-2-ylethylcarbamoyl)methyl]ethyl}carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

INHIBITORS OF DIPEPTIDYL PEPTIDASE IV

The invention relates to compounds of the formula (I) or pharmaceutically-acceptable salts thereof wherein Ar, R 1 , R2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 have any of the meanings defined in the description, which possess dipeptidyl peptidase IV (DPP-IV) inhibitory activity and accordingly have value in the treatment of disease states associated with DPP-IV activity, such as diabetes mellitus. Processes for the preparation of said compounds, intermediates in said processes, pharmaceutical compositions containing said compounds or salts, and the use of said compounds or salts are also described.

TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES

Compound of formula (I) or a pharmaceutically-acceptable salt thereof, formula (I) wherein Ar is optionally substituted phenyl; R1 is selected from: formula a) or b) (wherein is a single or double bond); R5, R6, R7/s