218615-81-7Relevant academic research and scientific papers
Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis
Ciccone, Lidia,Nencetti, Susanna,Nicolo, Tonali,Carole, Fruchart-Gaillard,William, Shepard,Elisa, Nuti,Caterina, Camodeca,Armando, Rossello,Orlandini, Elisabetta
, (2020)
Transthyretin (TTR) is a ?-sheet-rich homotetrameric protein that transports thyroxine (T4) and retinol both in plasma and in cerebrospinal fluid. TTR also interacts with amyloid-β, playing a protective role in Alzheimer's disease. Dissociation of the nat
COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE
-
Page 86, (2010/02/09)
Novel compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formula (1.4) or (1.5) wherein R, R and R are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.
