21869-84-1Relevant articles and documents
Leonard,Frihart
, p. 5894,5899 (1974)
Use of purine compound in treatment or prevention of hyperuricemic or gouty diseases
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Paragraph 0135; 0136; 0137, (2017/01/02)
The invention belongs to the technical field of medicines, relates to a use of a purine compound in treatment or prevention of hyperuricemic or gouty diseases, and concretely relates to a use of the purine compound concretely is a compound represented by formula (I), a pharmaceutically acceptable salt thereof, a solvate thereof or a composition containing anyone of the compound, the pharmaceutically acceptable salt and the solvate in the preparation of medicines for treating and/or preventing hyperuricemia, gouts, gouty inflammations and uratic nephropathy. In the formula (I), X represents a heteroaryl group selected from nitrogen-containing hetero atoms, Y represents a group selected from aryl groups or heteroaryl groups, the aryl groups or the heteroaryl groups are unsubstituted or are substituted with one or more halogen atoms or C-6 halogenated alkyl groups, m represents 3 or 4, and n represents 0 or 1.
Regioselective and efficient synthesis of N 7-substituted adenines, guanines, and 6-mercaptopurines
Maryska, Michal,Chudikova, Nadezda,Kotek, Vladislav,Dvorak, Dalimil,Tobrman, Tomas
, p. 501 - 507 (2013/07/26)
A simple and efficient protocol for the preparation of N 7-substituted adenines, guanines, and 6-mercaptopurines is described. The key step is the regioselective preparation of 7-substituted 6-chloropurines which are building blocks for the div
