21869-84-1

Usage

InChI:InChI=1/C8H9N5O/c1-2-3-13-4-10-6-5(13)7(14)12-8(9)11-6/h2,4H,1,3H2,(H3,9,11,12,14)

Upstream product

• 144364-09-0 7-allyl-2-amino-6-(trimethylsilylethoxy)purine 
• 141192-83-8 6-[2-(trimethylsilyl)ethoxy]-9H-purin-2-amine 
• 26578-09-6 guanosine 
• 106-95-6 allyl bromide 
• 118-00-3 G 
• 144364-03-4 7-allyl-2-amino-6-chloropurine 
• 10310-21-1 2-Amino-6-chloropurin 

Relevant academic research and scientific papers

PREVENTION OR TREATMENT OF URIC ACID OR GOUT DISEASE

The present invention relates to the use of a compound of formula (I), a pharmaceutically acceptable salt thereof, a solvate thereof, or a pharmaceutical composition containing the same in reducing uric acid level, preventing or reducing inflammations, and preventing or treating uratic or gouty diseases. In particular, the present invention relates to the use of a compound of formula (I), a pharmaceutically acceptable salt thereof, a solvate thereof, or a pharmaceutical composition containing the same in the manufacture of a medicament for the treatment or prevention of hyperuricemia, gout, gouty inflammations, pain and uric acid nephropathy. R1 represents hydrogen, C1-4alkyl or the like. R2 represents C1-10alkyl or the like. R3 represents halogen or the like.

Use of purine compound in treatment or prevention of hyperuricemic or gouty diseases

The invention belongs to the technical field of medicines, relates to a use of a purine compound in treatment or prevention of hyperuricemic or gouty diseases, and concretely relates to a use of the purine compound concretely is a compound represented by formula (I), a pharmaceutically acceptable salt thereof, a solvate thereof or a composition containing anyone of the compound, the pharmaceutically acceptable salt and the solvate in the preparation of medicines for treating and/or preventing hyperuricemia, gouts, gouty inflammations and uratic nephropathy. In the formula (I), X represents a heteroaryl group selected from nitrogen-containing hetero atoms, Y represents a group selected from aryl groups or heteroaryl groups, the aryl groups or the heteroaryl groups are unsubstituted or are substituted with one or more halogen atoms or C-6 halogenated alkyl groups, m represents 3 or 4, and n represents 0 or 1.

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

Regioselective and efficient synthesis of N 7-substituted adenines, guanines, and 6-mercaptopurines

A simple and efficient protocol for the preparation of N 7-substituted adenines, guanines, and 6-mercaptopurines is described. The key step is the regioselective preparation of 7-substituted 6-chloropurines which are building blocks for the div

XANTHINE DERIVATIVES WITH HM74A RECEPTOR ACTIVITY

The present invention relates to therapeutically active compounds of formula (I) which are xanthine derivatives, processes for the manufacture of said derivatives, pharmaceutical formulations containing the active compounds and the use of the compounds in

NOVEL COMPOUNDS

The present invention provides therapeutically active compounds which are xanthine derivatives, processes for the manufacture of said derivatives, pharmaceutical formulations containing the active compounds and the use of the compounds in therapy, particu

Regiochemistry and Stereochemistry in Pd(0)-Catalyzed Allylic Alkylation of Nucleoside Bases

Allylic alkylation of amino- and hydroxy-azaheterocycles, in particular nucleoside bases, has been effected using Pd(0)-catalysis.A method has been developed for the preparation of carbocyclic nucleoside analogs such as the antiviral agent Carbovir.The synthesis of an appropriately substituted cyclopentenyl acetate for this reaction is described.Carbocyclic nucleosides of thymine at N-1, of adenine at N-9 and guanine at N-9 are described.Regiochemistry and stereochemistry of the products and intermediates have been determined by NMR studies.The (trimethylsilyl)ethyl group has been found to be an excellent protecting group for the 6-OH group in guanine, and it is readily removed by fluoride ions.