21873-52-9

Basic information

• Product Name: 5,7-DICHLORO-4-HYDROXYQUINOLINE
• Synonyms: BUTTPARK 81\09-33;5,7-DICHLORO-4-QUINOLINOL;5,7-Dichloro-4-hydroxyquinoline97%
• CAS NO: 21873-52-9
• Molecular Formula: C₉H₅Cl₂NO
• Molecular Weight: 214.05
• Mol File: 21873-52-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 340.2°Cat760mmHg
• Flash Point: 159.5°C
• Appearance: /
• Density: 1.466g/cm³
• PKA: 0.52±0.50(Predicted)
• CAS DataBase Reference: 5,7-DICHLORO-4-HYDROXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DICHLORO-4-HYDROXYQUINOLINE(21873-52-9)
• EPA Substance Registry System: 5,7-DICHLORO-4-HYDROXYQUINOLINE(21873-52-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 21873-52-9(Hazardous Substances Data)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 626-43-7 3,5-Dichloroaniline 
• 157848-08-3 5,7-dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester 
• 33149-04-1 β-(3,5-dichloroanilino)propionitrile 
• 93514-82-0 ethyl 4-hydroxy-5,7-dichloroquinoline-3-carboxylate 
• 158591-48-1 4-hydroxy-5,7-dichloroquinoline-3-carboxylic acid 
• 131123-76-7 5,7-dichlorokynurenic acid 

Downstream Products

• 23834-01-7 4,5,7-trichloroquinoline 
• 124495-18-7 5,7-dichloro-4-(4-fluorophenoxy)quinoline 
• 5437-27-4 N⁴,N⁴-diethyl-N¹-(5,7-dichloro-[4]quinolyl)-1-methyl-butanediyldiamine 
• 203261-25-0 4-bromo-5,7-dichloroquinoline 

Relevant articles and documents

A phenoxy quinoline and its synthetic method (by machine translation)

The invention discloses a phenoxy quinoline and its synthetic method, the phenoxy quinoline comprises the following raw materials: water, ethyl acrylate, zinc chloride, glacial acetic acid, 3, 5 - dichloroaniline, ethanol, sodium hydroxide, toluene, poly phosphoric acid, n-octane, Pd/C catalyst, dichloroethane, phosphorus oxychloride, para-phenol and N, N - dimethyl formamide. This invention resulting of phenoxy quinoline content of greater than 98.0%, yield is 50% or more, the production cost is low, its synthetic combinations not needed in the process by the hydrolysis, such as high-temperature decarboxylation process, less operation step, mild reaction conditions, low equipment requirements, production of good product quality, is suitable for large-scale production enterprises. (by machine translation)

Method for preparing 4-hydroquinolines and/or tautomeric compounds

The invention concerns a method for preparing 4-hydroquinolines and/or tautomeric compounds. More particularly, the invention concerns 5,7-dichloro-4-quinolines and/or its tautomeric compounds. The method is characterized in that it consists in heating a 4-hydroquinolinecarboxylic acid, its derivatives or precursors, at a temperature not more than 200° C. in the presence of a base.

Catalytic enantioselective reissert-type reaction: Development and application to the synthesis of a potent NMDA receptor antagonist (-)-L-689,560 using a solid-supported catalyst

Full details of the first catalytic enantioselective Reissert-type reaction are described. Utilizing the Lewis acid-Lewis base bifunctional catalyst 5 or 6 (9 mol %), the Reissert products were obtained in 57 to 99% yield with 54 to 96% ee. Electron-rich