218771-60-9Relevant academic research and scientific papers
A new chiral C1-symmetric NHC-catalyzed addition to α-aryl substituted α,β-disubstituted enals: Enantioselective synthesis of fully functionalized dihydropyranones
Lu, Hong,Liu, Jin-Yu,Li, Chen-Guang,Lin, Jun-Bing,Liang, Yong-Min,Xu, Peng-Fei
, p. 4473 - 4476 (2015)
The first enantioselective NHC-catalyzed activation of α-aryl substituted α,β-disubstituted unsaturated aldehyde is successfully developed via a highly-active acyl azolium intermediate. The new C1-symmetric biaryl-saturated imidazolium exhibits a superior ability to enable previously unavailable transformation, and the corresponding fully functionalized dihydropyranones are efficiently synthesized in high yields with excellent enantioselectivities. This journal is
