21878-27-3Relevant articles and documents
Computer-aided design, synthesis and validation of 2-phenylquinazolinone fragments as CDK9 inhibitors with anti-HIV-1 tat-mediated transcription activity
Sancineto, Luca,Iraci, Nunzio,Massari, Serena,Attanasio, Vanessa,Corazza, Gianmarco,Barreca, Maria Letizia,Sabatini, Stefano,Manfroni, Giuseppe,Avanzi, Nilla Roberta,Cecchetti, Violetta,Pannecouque, Christophe,Marcello, Alessandro,Tabarrini, Oriana
, p. 1941 - 1953 (2013)
The activity of the cyclin-dependent kinase 9 (CDK9) is critical for HIV-1 Tat-mediated transcription and represents a promising target for antiviral therapy. Here we present computational studies that, along with preliminary synthetic efforts, allowed us
