218799-02-1Relevant articles and documents
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation
Paterson, Ian,Chen, David Y.-K.,Coster, Mark J.,Acena, Jose L.,Bach, Jordi,Wallace, Debra J.
, p. 2431 - 2440 (2005)
The antimitotic marine macrolide altohyrtin A/spongistatin 1 (1) has been synthesised in a highly convergent and stereocontrolled manner, thus contributing to the replenishment of the largely exhausted material from the initial isolation work. Coupling of
Studies in marine macrolide synthesis: Synthesis of a fully functionalised C1-C28 subunit of spongistatin 1 (Altohyrtin A)
Paterson, Ian,Wallace, Debra J.,Oballa, Renata M.
, p. 8545 - 8548 (2007/10/03)
The C1-C28 aldehyde 5, containing the AB- and CD-spiroacetal portions together with the bridging chain of spongistatin 1 (1), was prepared. The key step was a lithium-mediated, anti-aldol coupling between ethyl ketone 4 and aldehyde